Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2209294..2209880 | Replicon | chromosome |
| Accession | NZ_CP096843 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb3602 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | M1781_RS10335 | Protein ID | WP_003410010.1 |
| Coordinates | 2209294..2209638 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | M1781_RS10340 | Protein ID | WP_003410014.1 |
| Coordinates | 2209632..2209880 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1781_RS10300 (M1781_10310) | 2205000..2205599 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
| M1781_RS10305 (M1781_10315) | 2206015..2206443 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| M1781_RS10310 (M1781_10320) | 2206669..2207208 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| M1781_RS10315 (M1781_10325) | 2207728..2208288 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| M1781_RS10320 (M1781_10330) | 2208285..2208626 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| M1781_RS10325 (M1781_10335) | 2208712..2208969 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| M1781_RS10330 (M1781_10340) | 2208870..2209205 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| M1781_RS10335 (M1781_10345) | 2209294..2209638 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| M1781_RS10340 (M1781_10350) | 2209632..2209880 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| M1781_RS10345 (M1781_10355) | 2209980..2212295 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| M1781_RS10350 (M1781_10360) | 2212292..2212564 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| M1781_RS10355 (M1781_10365) | 2212617..2212973 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| M1781_RS10360 (M1781_10370) | 2213130..2213897 | + | 768 | WP_003410019.1 | hemerythrin domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T243763 WP_003410010.1 NZ_CP096843:c2209638-2209294 [Mycobacterium tuberculosis variant bovis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T243763 NZ_OX461105:467909-468187 [Serratia proteamaculans]
ATGCGTGTCGAATGGGATGATGAAGCGCTATTGGACAGGGAACGTATTTTTGATTTTCTCTATCCCTTTAATCCACAGGC
TGCTGAGCAGGCTGATAGTGAGATTGATAAGGCAGTGAAGCGCCTGTTGGATTACCCTGAACTCGGTAAAATTTGGTACG
GACAGGCGCGTAAATTATTGATCAGTCAAGCTTCATTATTAGTTTTATACGTTGTTGTCGGCGACGTGATTAAGGTTTTA
GCCGTTGCCCATCAACGAGAGAAATTCCCTGACTTATAG
ATGCGTGTCGAATGGGATGATGAAGCGCTATTGGACAGGGAACGTATTTTTGATTTTCTCTATCCCTTTAATCCACAGGC
TGCTGAGCAGGCTGATAGTGAGATTGATAAGGCAGTGAAGCGCCTGTTGGATTACCCTGAACTCGGTAAAATTTGGTACG
GACAGGCGCGTAAATTATTGATCAGTCAAGCTTCATTATTAGTTTTATACGTTGTTGTCGGCGACGTGATTAAGGTTTTA
GCCGTTGCCCATCAACGAGAGAAATTCCCTGACTTATAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT243763 WP_003410014.1 NZ_CP096843:c2209880-2209632 [Mycobacterium tuberculosis variant bovis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT243763 NZ_OX461105:467613-467900 [Serratia proteamaculans]
ATGGAAAGTCGTATCCAGTTTCGCATTGAGGATGAGACTAAACGTTTGGCGCAGAAAGCCGCAGAAGCCAAAGGGATCAC
TTTGAGCGAGGCGTGTCGACGTTTGGCTGAGCAAATGGCGGATGAGCAACGGGCAGCTGAGCAACATGAAAATTGGTTGA
AAGAAAAGGTTGATGCCGCTTTTTCCCGTCTACATGAAGGAAGTGCGGTCTATCTTAGCCAAGAGCAGGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAGTCCGGGCGAAATACGACCAAAAATAG
ATGGAAAGTCGTATCCAGTTTCGCATTGAGGATGAGACTAAACGTTTGGCGCAGAAAGCCGCAGAAGCCAAAGGGATCAC
TTTGAGCGAGGCGTGTCGACGTTTGGCTGAGCAAATGGCGGATGAGCAACGGGCAGCTGAGCAACATGAAAATTGGTTGA
AAGAAAAGGTTGATGCCGCTTTTTCCCGTCTACATGAAGGAAGTGCGGTCTATCTTAGCCAAGAGCAGGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAGTCCGGGCGAAATACGACCAAAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|