Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2207728..2208626 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag M1781_RS10315 Protein ID WP_003410001.1
Coordinates 2207728..2208288 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag M1781_RS10320 Protein ID WP_003410003.1
Coordinates 2208285..2208626 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS10285 (M1781_10295) 2202897..2203550 - 654 WP_003409976.1 cutinase Cfp21 -
M1781_RS10290 (M1781_10300) 2203665..2203895 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1781_RS10295 (M1781_10305) 2203980..2204891 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1781_RS10300 (M1781_10310) 2205000..2205599 + 600 WP_003409989.1 L-lysine exporter -
M1781_RS10305 (M1781_10315) 2206015..2206443 + 429 WP_003409992.1 cellulose-binding protein -
M1781_RS10310 (M1781_10320) 2206669..2207208 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1781_RS10315 (M1781_10325) 2207728..2208288 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
M1781_RS10320 (M1781_10330) 2208285..2208626 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
M1781_RS10325 (M1781_10335) 2208712..2208969 + 258 WP_003410006.1 hypothetical protein -
M1781_RS10330 (M1781_10340) 2208870..2209205 - 336 WP_003410009.1 dehydrogenase -
M1781_RS10335 (M1781_10345) 2209294..2209638 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
M1781_RS10340 (M1781_10350) 2209632..2209880 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
M1781_RS10345 (M1781_10355) 2209980..2212295 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1781_RS10350 (M1781_10360) 2212292..2212564 - 273 WP_003410017.1 DUF1490 family protein -
M1781_RS10355 (M1781_10365) 2212617..2212973 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T243762 WP_003410001.1 NZ_CP096843:c2208288-2207728 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T243762 NZ_OX461105:68006-68662 [Serratia proteamaculans]
ATGGCGAACTATAAAAGCCTGAATCCCCAGAAAGCGCTGATTTGGCGCATCGTTCACAAGGATAATCTTCCTTGGATCCT
GGCTAATGGTTTGCATGCCGGCAGTAGCGAGAAAAAAGCGTCTGACTGGGTGAGTATCGGCAACACGGAGCTCATTGAGC
GTCGTAAACACCGTAAGGTGCCTGTAGCACCCGGTGGGACACTGGATGACTATATCCCTTTCTATTTCACTCCTTTTTCG
CCGATGCTGTACAATATTCATACTGGCCGTGGTGGTGTAGCCCGGCAAGCTAACGAAGACATTGTCATTTTGGTTTCAAG
CCTGCATCGGTTACAGCAGCAGGAGCGGGTTTTTGTATTTACCGATCGCCATGCATATACCCCTATGGCAGGTTACTACA
GCCACCTTGCGCAGTTAGATAAAATTGATTGGGAACTGTTACAGCAACGTAATTTTAACCGAGTACCCGATAAACCTGAG
CAAATTGAACGGTACCAGGCTGAAGCCTTGGTTCATCACCATTTGCCCGTCACCGCATTGTTGGGGATTGTTTGTTATAG
CTCGGCGTTACAAGAAAAATTGCAAAAAGAATTCGGTCATTTACTGAACATACAGTGCTTGCCAGATTGGTATTTTAATG
GTGGGGGGAACCAATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT243762 WP_003410003.1 NZ_CP096843:c2208626-2208285 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT243762 NZ_OX461105:68659-69735 [Serratia proteamaculans]
ATGATTCGTTTTACACAAGGTAACCTGTTAGATGCGCCCGTAGAGGCGCTCGTCAATACTGTTAATACCGTCGGTGTCAT
GGGCAAAGGTATTGCCCTGATGTTCAAAGAACGTTTCCCGGCCAATATGAAAGCCTATTCTGCGGCGTGTAAGGCCGAGA
CGGTGCAAACGGGCAAAATGTTCGTTACTGATACCGGGGAGCTAATGGGGCCGCGTTGGATTATTAATTTTCCAACCAAA
CAACATTGGCGCAGTCCGTCCAAATTAGAGTGGATTGTTGAAGGGTTACGCGATCTGCGCCGCTTTATCATGCAAAACAA
TATAGCTTCAATTGCCATCCCACCTCTTGGGGCTGGGCATGGTGGGCTAGACTGGGTTGCGGTTCGTGATGTGATTATTC
AAGAACTCAGCGATTTGCCACAGGTGGATATCATTATTTATGAACCCATTGAAAAATATCAGAATGTGGCAAAAAGCGTG
GGTGTTGAAAAACTCACCCCAGCTCGGGCGCTGATCGCGGAGTTGGTCCGTCGCTATTGGGTCTTGGGGATGGAGTGCAG
TTTACTTGAAATACAAAAGCTGGCGTGGTTCCTGGAGCGCGCAATCATCGCTCAACAAGTTGAAAATCCCTTGAATCTTC
AGTTTAAAGCTCAGAACTATGGCCCTTATGCGGACAGACTACGTCATTTGCTTAACGGGTTGGATGGGAGCTATTTACGG
TGTGAGAAACGGCTGGGGGATGCCAAGCCTTTGGATATCATCTGGTTTAATGATGCTAAGCGCGATGTGGTTCTTGCCTA
TCTCAAAAGCGAAGCTAAAACCTGGTTACCCGCGTTGCAGAAGACAACGGAGTTGATTGATGGCTTTGAATCGCCTTATG
GACTGGAATTGCTCTCGACAATCGATTGGTTAGTCTACCAGGAACATATCTCTGCTGATGAAGAATCACTAGCGGAAGGA
ATTCGCCACTGGCCAGCAGGTGAGCGTTGGGCGCAACGGAAGTCGGGATTGTTCGACAAGACGGCAATAAATATGGCGTT
AACCCGCTTACAAACATTATATCCCCCTCATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References