Detailed information of TA system TA024376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxT-higA/Tad-HTH_XRE
• Location: 1364689..1365326
• Replicon: chromosome
• Accession: NC_013385
• Organism: Ammonifex degensii KC4

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: C9R833
• Locus tag: ADEG_RS06865
• Protein ID: WP_015739339.1
• Coordinates: 1364689..1365048 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ADEG_RS06870
• Protein ID: WP_169302584.1
• Coordinates: 1365075..1365326 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADEG_RS06820	1359807..1360138	-	332	Protein_1346	transposase	-
ADEG_RS11370	1360138..1360566	-	429	WP_015739332.1	DUF3368 domain-containing protein	-
ADEG_RS06830	1360611..1360886	-	276	WP_211204548.1	UPF0175 family protein	-
ADEG_RS06835	1360900..1361301	-	402	WP_015739334.1	DUF5615 family PIN-like protein	-
ADEG_RS06840	1361298..1361552	-	255	WP_015739335.1	DUF433 domain-containing protein	-
ADEG_RS06845	1361856..1363265	-	1410	WP_015739336.1	EAL domain-containing protein	-
ADEG_RS06850	1363421..1363831	+	411	WP_015739337.1	hypothetical protein	-
ADEG_RS11990	1363975..1364127	-	153	Protein_1353	transposase	-
ADEG_RS06860	1364387..1364581	-	195	WP_156779937.1	helix-turn-helix domain-containing protein	-
ADEG_RS06865	1364689..1365048	+	360	WP_015739339.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ADEG_RS06870	1365075..1365326	+	252	WP_169302584.1	helix-turn-helix transcriptional regulator	Antitoxin
ADEG_RS06875	1365451..1367442	-	1992	WP_015739341.1	type IV secretory system conjugative DNA transfer family protein	-
ADEG_RS06880	1367449..1367883	-	435	WP_015739342.1	hypothetical protein	-
ADEG_RS06885	1367850..1368128	-	279	WP_015739343.1	hypothetical protein	-
ADEG_RS06890	1368241..1368582	-	342	WP_015739344.1	hypothetical protein	-
ADEG_RS06895	1368603..1368860	-	258	WP_015739345.1	hypothetical protein	-
ADEG_RS06900	1368866..1369165	-	300	WP_015739346.1	hypothetical protein	-
ADEG_RS06905	1369268..1370269	-	1002	WP_015739347.1	ParM/StbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-75)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13618.76 Da
• Isoelectric Point: 10.1720

>T24376 WP_015739339.1 NC_013385:1364689-1365048 [Ammonifex degensii KC4]
MREIIFYETPSGRCPVADYIAGLDARTQAKVARALDLLEEHGPAIGMPHVRRLEGTEGIFELRVPFGGQAHRLLFFLDGE
KIVVVHAFTKKSSKTPKNEIQTAVLRMDDYLRRERRKNR

Nucleotide

• Length: 360 bp

>T24376 NC_013385:1364689-1365048 [Ammonifex degensii KC4]
ATGCGGGAAATAATCTTCTACGAGACGCCGTCGGGAAGATGCCCCGTAGCCGACTACATTGCCGGTCTTGATGCCAGAAC
GCAAGCTAAGGTGGCCCGTGCCCTGGACCTCCTGGAAGAACACGGCCCGGCGATCGGAATGCCCCACGTCAGGCGGCTGG
AAGGAACTGAAGGCATCTTCGAGCTGCGGGTTCCGTTCGGGGGCCAGGCGCATCGCTTGCTGTTCTTCCTGGACGGCGAG
AAAATAGTGGTGGTTCACGCTTTTACCAAGAAAAGTAGTAAGACGCCGAAAAACGAAATCCAAACCGCAGTCCTGCGCAT
GGATGATTACCTCAGAAGAGAAAGGAGGAAGAATCGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9572.04 Da
• Isoelectric Point: 10.2071

>AT24376 WP_169302584.1 NC_013385:1365075-1365326 [Ammonifex degensii KC4]
MENPEFVKEYEALGPEYRLLAELVRRRLEKGLTQEELARRIGTRQSAIARLESGRTSPTLRMLKKVADALDADLEVRLRP
RHG

Nucleotide

• Length: 252 bp

>AT24376 NC_013385:1365075-1365326 [Ammonifex degensii KC4]
ATGGAAAACCCGGAGTTTGTGAAAGAGTATGAAGCTCTAGGGCCTGAGTACCGGCTCTTAGCCGAGCTTGTCCGGCGGCG
CCTGGAAAAGGGCCTCACGCAGGAGGAGCTGGCCCGCAGGATCGGTACCAGGCAGTCCGCAATCGCCAGGCTGGAAAGCG
GGCGCACAAGCCCCACGCTCCGGATGCTCAAGAAGGTGGCCGACGCGCTGGACGCCGACCTGGAGGTCAGGCTCCGCCCC
CGCCACGGCTAA

Structures

Toxin

• AlphaFold DB: C9R833