Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1687729..1688345 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag M1781_RS07965 Protein ID WP_003407593.1
Coordinates 1688028..1688345 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag M1781_RS07960 Protein ID WP_003900349.1
Coordinates 1687729..1688031 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS07950 (M1781_07950) 1683615..1685462 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
M1781_RS07955 (M1781_07955) 1685463..1687715 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
M1781_RS07960 (M1781_07960) 1687729..1688031 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
M1781_RS07965 (M1781_07965) 1688028..1688345 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
M1781_RS07970 (M1781_07970) 1688342..1689346 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
M1781_RS07975 (M1781_07975) 1689399..1690688 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
M1781_RS07980 (M1781_07980) 1690761..1691378 - 618 WP_003407606.1 class I SAM-dependent methyltransferase -
M1781_RS07985 (M1781_07985) 1691592..1691783 - 192 WP_003407609.1 dodecin family protein -
M1781_RS07990 (M1781_07990) 1691865..1692263 + 399 WP_003900351.1 hypothetical protein -
M1781_RS07995 (M1781_07995) 1692308..1693336 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-99)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T243754 WP_003407593.1 NZ_CP096843:1688028-1688345 [Mycobacterium tuberculosis variant bovis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T243754 NZ_OX460985:c1327473-1326703 [Streptococcus agalactiae]
ATGACATTAGCAGAATATAGTGAGGCGGAGTTTCAAAAGGCTTTAAGGCGTAATATTCGTGCTTTAACCCGTGGCAAAAC
TATTTCCTCAACTCCCAAAGCAGTTCTGCTTGGTGGTCAAAGTGGAGCTGGAAAAACGACCATTCATCGAATCAAGCAAA
AGGAATTTCAAGGGAATATCATCATTATTGACGGAGATAGCTTCCGTTCGCAGCATCCAAATTATCTGGCTTTGCAGGAA
GAGTATGGCAAATATAGCGTTGATTATACCAAAGATTTTGCGGGGAAGATGGTTGAACACCTCATTGGTGAACTCAGCAA
ACAAAGCTATCATTTATTAATTGAGGGAACACTGAGAACAACAGAAGTCCCTCGAAAAACAGCTCAATTATTAAAATCAA
GAGGCTATCAAGTATCACTTGCGCTCATCGCAACAAAGCCAGAACTGTCCTATCTTAGCACCTTGATACGCTATGAAGAA
CTTTATGCCATAGATCCTAATCAAGCCAGAGCAACACCAAAAGAATATCATGATGGGATTGTGGAACACTTGGTTGATAA
TCTACGAGAGTTAGAAAATGATAAACTTTTTAACCGGATTCAAATCTATCAAAGAGATAGACATTGTGTCTATGATTCTG
AAACTGATAAAGGCATAGCTGCAGAAGTGCTTCAAGAATGTCTCTTTGGGAAATGGAGTAAGGTAGAGGAGGAGATGTTG
AGGGTGGGACAGGAACGGTTGAGGGAGTTAAGTATGAGAACCCCAAAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT243754 WP_003900349.1 NZ_CP096843:1687729-1688031 [Mycobacterium tuberculosis variant bovis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT243754 NZ_OX460985:c1327949-1327473 [Streptococcus agalactiae]
ATGATTGGAGATAATATTAAGTCCTTACGACGAACACATGATTTAACGCAGCCAGAGTTCGCAAAAATTATTGGTATTTC
AAGGAATAGTCTTAGTCGTTATGAAAATGGAACCAGCTCCGTTTCAACCGAACTCATTGATCGGATTTGTCAGAAATTTA
ATGTGTCTTATGTCGATATTGTTGGAGAAGATAAGATGATGACACCCGTAGAAGATTATCAGCTGACTATAAAAATTGAA
GTACTGAAAGAACGAGGTTCTGCCATTTTGTCAAGGCTGTACCGCCATCAAGATGAGCAAGGGATTGCATTTGACGATGA
ATCGAATCCGTGGATTTTGATAAGTGATGATGTAGCAGATTTAGTGAATACCAAGATTTATCTTGTCGATACCTTTGAAG
AGTTAGAGCGTTACAATGGCTATTTAGATGGTATTGAGCGGATGTTAAACCTTGCCAATCACCAGGTGGTGGCCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2


Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References