Detailed information of TA system TA243751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1390343..1390902
• Replicon: chromosome
• Accession: NZ_CP096843
• Organism: Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: M1781_RS06655
• Protein ID: WP_003898789.1
• Coordinates: 1390343..1390636 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: M1781_RS06660
• Protein ID: WP_003406322.1
• Coordinates: 1390633..1390902 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1781_RS06630 (M1781_06625)	1385937..1386197	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
M1781_RS06635 (M1781_06630)	1386194..1386625	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
M1781_RS06640 (M1781_06635)	1386648..1388335	-	1688	Protein_1310	PE family protein	-
M1781_RS06645 (M1781_06640)	1388515..1389375	+	861	WP_003406306.1	glycine betaine ABC transporter substrate-binding protein	-
M1781_RS06650 (M1781_06645)	1389456..1390286	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
M1781_RS06655 (M1781_06650)	1390343..1390636	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
M1781_RS06660 (M1781_06655)	1390633..1390902	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1781_RS06665 (M1781_06660)	1391015..1394710	-	3696	WP_010950509.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
M1781_RS06670 (M1781_06665)	1394852..1395640	-	789	WP_010950510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T243751 WP_003898789.1 NZ_CP096843:c1390636-1390343 [Mycobacterium tuberculosis variant bovis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T243751 NZ_OX460977:c9896-9630 [Carnobacterium maltaromaticum]
TTGGGATACTCTATAAAGTTAGCAAAATCAACAATGAAAGACCTTAAAAATTTAAAATCGGCTCATTTAGAGCAAAAATT
TAAAGATATAATGGAAATTTTAAAAGAGAACCCGTTTCAAAATCCACCGCCTTATGAGAAGCTAGTCGGAAATTTAAAAG
ATAACTATTCCCGACGATTAAATATTCAACACCGAGTGGTTTACTCGGTTGATAATGACGCAAAAGAAGTCATTATTTGG
TCGGCTTGGACGCACTACGAAAGATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT243751 WP_003406322.1 NZ_CP096843:c1390902-1390633 [Mycobacterium tuberculosis variant bovis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT243751 NZ_OX460977:c10135-9881 [Carnobacterium maltaromaticum]
ATGTCTATCGTAAACCCTAGCCAAGCTAGAAAAGTCTTTTATCAACTATTGAAAGACGTCAATAAAACTAACGAACCCAT
TTATATCTCTGGCAAAAACGAAGAAAGTGAAGCCGTTATGGTCAGTAAAAAAGACTGGGACGCAATTCAAGAAACATTAT
ACCTTCAATCTGCTGGCGTAGCAGATGTGATCCACCAGCGTGAACAAGAAAATGAGTTTGTTGCATTGGAGGATATCGAT
TGGGATACTCTATAA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2