Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 842950..843659 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag M1781_RS03985 Protein ID WP_003403837.1
Coordinates 843231..843659 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag M1781_RS03980 Protein ID WP_003403834.1
Coordinates 842950..843207 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS03975 (M1781_03975) 840132..842859 + 2728 Protein_786 PE family protein -
M1781_RS03980 (M1781_03980) 842950..843207 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
M1781_RS03985 (M1781_03985) 843231..843659 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS03990 (M1781_03990) 843740..843877 - 138 WP_003403839.1 hypothetical protein -
M1781_RS03995 (M1781_04000) 844036..844281 + 246 WP_003403841.1 hypothetical protein -
M1781_RS04000 (M1781_04005) 844350..845234 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
M1781_RS04005 (M1781_04010) 845245..846417 - 1173 WP_079293715.1 acyl-CoA dehydrogenase family protein -
M1781_RS04010 (M1781_04015) 846424..847956 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T243744 WP_003403837.1 NZ_CP096843:843231-843659 [Mycobacterium tuberculosis variant bovis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T243744 NZ_OX460963:c4186003-4185683 [Hafnia paralvei]
ATGCATACTTCAACTGTACCGGCCACGGTGCCAGTTTCGTCACGCCTGCCGCCCGTGCAGGTCTGGCAGCAACTATTAAC
TTATCTGCTGGAACACCATTACGGTCTAACGCTAAACGACACACCATTCCACGATGATTCAGCTATTCAGGAACATATCG
AAGCAGGAATAACACTGGCTGATGCGGTGAATTTTCTGGTGGAACGCTATGAACTGATACGCACTGACCGTAAAGGGTTT
ACATGGCAAGAGCAGACACCATTTCTGACCGCTATCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATGAATATATA
A

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT243744 WP_003403834.1 NZ_CP096843:842950-843207 [Mycobacterium tuberculosis variant bovis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT243744 NZ_OX460963:c4186363-4186040 [Hafnia paralvei]
ATGTCATTTACATCACCTCATGAATGGGGGCTACTAAGCGATATCACCCCACGATTTGGCGCAAGATTAGTTCAGGAAGG
CAACCGGCTGTATTACCTGGCTGACAGGGCTGGATTTACGGGGAGTTTTAGCCCGATACACCTGAAGAAATTAGATCTGG
CTTTCCCGCTGTTTGTAGAGCAACTGGAAGATATGCTGCGTGCTGGCGAACTAAATCCACATCAGCAACGTCAGGTGACC
ATTCAACTTGCGAGTGTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCGACCTT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References