Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 756564..757356 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag M1781_RS03505 Protein ID WP_003403386.1
Coordinates 756919..757356 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag M1781_RS03500 Protein ID WP_003403381.1
Coordinates 756564..756809 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS03470 (M1781_03470) 751584..753089 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
M1781_RS03475 (M1781_03475) 753170..754180 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1781_RS03480 (M1781_03480) 754568..754951 - 384 WP_003403365.1 ribonuclease VapC6 -
M1781_RS03485 (M1781_03485) 755046..755201 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
M1781_RS03490 (M1781_03490) 755277..755993 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1781_RS03495 (M1781_03495) 756269..756577 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
M1781_RS03500 (M1781_03500) 756564..756809 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
M1781_RS03505 (M1781_03505) 756919..757356 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS03510 (M1781_03510) 757353..757607 - 255 WP_003911263.1 antitoxin VapB7 -
M1781_RS03515 (M1781_03515) 757721..760084 + 2364 WP_003403397.1 arylsulfatase AtsD -
M1781_RS03520 (M1781_03520) 760147..760473 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1781_RS03525 (M1781_03525) 760385..760723 + 339 WP_003403405.1 PIN domain-containing protein -
M1781_RS03530 (M1781_03530) 760720..760893 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T243742 WP_003403386.1 NZ_CP096843:c757356-756919 [Mycobacterium tuberculosis variant bovis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T243742 NZ_OX460963:3480855-3481058 [Hafnia paralvei]
ATGACTAAAATTGATTACCTGATGCGTTTGCGTAAGTGCACTACCTTAGACACTCTCGAACGCGTGATTGAAAAAAATAA
GTATGAACTTTCCGACGATGAGCTAGAGACCTTCTACTCTGCGGCAGATCACCGTCTGGCAGAGCTAACGATGAACAAGC
TATATGACAAGATCCCAGCGGAAGTGTGGAAGTATGTACGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT243742 WP_003403381.1 NZ_CP096843:c756809-756564 [Mycobacterium tuberculosis variant bovis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT243742 NZ_OX460963:3480467-3480841 [Hafnia paralvei]
ATGGATGAATATACGTCTTATCAGCACGATATTACGGAGCTGAAATATCTATGTAATATGTTGTACAATCAAGGAATGGA
TGTTCTGAGCGATAGCCATCATGGCTGGGTCAACGACCCAACAGCAGTGGACAATCTACAACTAAATGAATTAAACGAAC
ATATTGCAAATTTTGGTTTAACATTCAAGATTAAGTATCCAAATGCTTCAGAATTAACTGAAATATTAGATGAGTATCTT
GACGAAACATACAGTCTGTTTAGTAATTACAGTATCAACGAACCAGAACTTAAAAAATGGCTTAAAGCAAAAGGCCGTAT
TTTGCGTTATTTAGCGGGTGAAAAAACCACATCTGCATTAAATTTTAACCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References