Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 754568..755201 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag M1781_RS03480 Protein ID WP_003403365.1
Coordinates 754568..754951 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag M1781_RS03485 Protein ID WP_003403368.1
Coordinates 755046..755201 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS03455 (M1781_03455) 749860..750396 + 537 WP_003403341.1 50S ribosomal protein L10 -
M1781_RS03460 (M1781_03460) 750433..750825 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
M1781_RS03465 (M1781_03465) 750818..751513 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
M1781_RS03470 (M1781_03470) 751584..753089 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
M1781_RS03475 (M1781_03475) 753170..754180 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1781_RS03480 (M1781_03480) 754568..754951 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
M1781_RS03485 (M1781_03485) 755046..755201 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1781_RS03490 (M1781_03490) 755277..755993 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1781_RS03495 (M1781_03495) 756269..756577 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
M1781_RS03500 (M1781_03500) 756564..756809 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
M1781_RS03505 (M1781_03505) 756919..757356 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
M1781_RS03510 (M1781_03510) 757353..757607 - 255 WP_003911263.1 antitoxin VapB7 -
M1781_RS03515 (M1781_03515) 757721..760084 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T243740 WP_003403365.1 NZ_CP096843:c754951-754568 [Mycobacterium tuberculosis variant bovis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T243740 NZ_OX460963:2477370-2477894 [Hafnia paralvei]
ATGCCAGATCTCGCTATTGAGATTTTTTCGAACGACATCGAATATGATTTTGCTCATTTCGACTGTGGTGAAGAATCTCT
CAATATATTCCTCACCAATCATCTTGCCCGCCAGCACAACTCTCGAATCTTACGGGGTTATTTGCTGGTCACCAAAGAGC
CAAAACCTAAAATCGTAGGATATTACACGTTATCTGGCAGTTGCTTCGAGAAAGAAACGCTTCCCTCAAACACACAGAAA
CGGAAAGTACCTTACGCTAATGTGCCCAGCGTCACCTTGGGGCGACTGGCTATCCAAAAAGAGTTGCAGGGACAAGACTG
GGGAACAACGCTGGTAACTCATGCTATGAAAGTCATCTATCACGCGTCACTGGCGGTCGGCATCCATGGTATGTTTGTTG
ATGCCCTTAACGAAAAAGCCAAGCGGTTCTATCTTCAACTTGGTTTTATTGCACTTACAGGCAATAACGCAAACTCGTTG
TTCTACCCAACGAAATCCATCGAAAAGCTGTTTGAAGACGAATAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT243740 WP_003403368.1 NZ_CP096843:c755201-755046 [Mycobacterium tuberculosis variant bovis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT243740 NZ_OX460963:2477097-2477366 [Hafnia paralvei]
ATGTCCGCCCTAAAAAAACAACGTATCGATCTCAGACTCACCGATGATGACAAAAGCAAGATCGAAGAAGCGGCCGCAAT
GACCAACCAAACTATCACCCAGTTTATGGTTGCTAGCGCCGCTGAACGCGCAGAGGAAGTCATTGAGCAGCATCGTCGTC
TCGTTCTCAACGATGAGTCGTGGAATTTGGTGATGGACGCTATCAGCAATCCGCCAGCCCCGAACAGTCGGCTGAAACGA
GCAGCGAAACGTCTAGCAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References