Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 711842..712467 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag M1781_RS03260 Protein ID WP_003403218.1
Coordinates 712066..712467 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag M1781_RS03255 Protein ID WP_003403213.1
Coordinates 711842..712069 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS03230 (M1781_03230) 707021..707242 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1781_RS03235 (M1781_03235) 707384..707989 + 606 WP_003898526.1 hypothetical protein -
M1781_RS03240 (M1781_03240) 708008..710575 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
M1781_RS03245 (M1781_03245) 710659..711408 + 750 WP_003898528.1 hypothetical protein -
M1781_RS03250 (M1781_03250) 711405..711647 + 243 WP_003403210.1 hypothetical protein -
M1781_RS03255 (M1781_03255) 711842..712069 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
M1781_RS03260 (M1781_03260) 712066..712467 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
M1781_RS03265 (M1781_03265) 712596..712679 + 84 Protein_647 galactose-1-phosphate uridylyltransferase -
M1781_RS03270 (M1781_03270) 712698..713780 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1781_RS03275 (M1781_03275) 713777..714868 + 1092 WP_003403225.1 galactokinase -
M1781_RS03280 (M1781_03280) 715263..716420 + 1158 WP_003903091.1 hypothetical protein -
M1781_RS03285 (M1781_03285) 716431..717378 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T243737 WP_003403218.1 NZ_CP096843:712066-712467 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T243737 NZ_OX460963:743629-743970 [Hafnia paralvei]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGACGAAGCCCTGTCTGTCGCACGTGGCTGTCTGGCAAATGTTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACAACACGCCGTTCAGTGATGAAACTGTTATTCAGGAACACATAG
ACGCCGGTATCACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATATGAACTGGTTCGTATTGATCGAAGAGGATTT
AGTTGGCAGGAACAATCACCTTATCTTCGGGCTGTAGATATCCTGCGAGCACGACAAGCAACTGGCTTGTTGCGACGGAG
CCATAATAACGCTGTATTGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT243737 WP_003403213.1 NZ_CP096843:711842-712069 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT243737 NZ_OX460963:743288-743608 [Hafnia paralvei]
ATGAGAAGTAACGTCACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCA
ACTGCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCC
CGCACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGCGTCATCCTGTAT
CACAACGGTTTCACCTGCGAAGCCGACACGCTTGGCAGTTGCGGCTATGTATACATCGCCGTCTATCCCACTCAACGCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References