243736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704304..704947 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag M1781_RS03210 Protein ID WP_003403187.1
Coordinates 704546..704947 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag M1781_RS03205 Protein ID WP_003403184.1
Coordinates 704304..704549 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS03170 (M1781_03170) 699584..700114 - 531 WP_003917320.1 two component system sensor kinase HK2 -
M1781_RS03175 (M1781_03175) 700098..700793 - 696 WP_197044064.1 two-component system response regulator TcrA -
M1781_RS03180 (M1781_03180) 700916..701227 + 312 WP_003403164.1 hypothetical protein -
M1781_RS03185 (M1781_03185) 701299..702249 + 951 WP_003907436.1 DUF1259 domain-containing protein -
M1781_RS03190 (M1781_03190) 702490..703074 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
M1781_RS03195 (M1781_03195) 703076..703786 + 711 Protein_633 IS607 family element RNA-guided endonuclease TnpB -
M1781_RS03200 (M1781_03200) 703789..704259 + 471 WP_003898523.1 hypothetical protein -
M1781_RS03205 (M1781_03205) 704304..704549 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1781_RS03210 (M1781_03210) 704546..704947 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS03215 (M1781_03215) 704938..705117 + 180 Protein_637 hypothetical protein -
M1781_RS03220 (M1781_03220) 705535..705732 - 198 WP_003403191.1 hypothetical protein -
M1781_RS03225 (M1781_03225) 705812..706969 - 1158 WP_003403193.1 hypothetical protein -
M1781_RS03230 (M1781_03230) 707021..707242 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1781_RS03235 (M1781_03235) 707384..707989 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T243736 WP_003403187.1 NZ_CP096843:704546-704947 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T243736 NZ_OX460960:1454464-1455309 [Streptococcus agalactiae]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTAATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCGAATAACACTTTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAGATTTTAGCAGATTCCGAAGAGGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT243736 WP_003403184.1 NZ_CP096843:704304-704549 [Mycobacterium tuberculosis variant bovis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT243736 NZ_OX460960:1453877-1454467 [Streptococcus agalactiae]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGAATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGGATTATTTACCGCATCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGATGAATACTACTTCTTTCAGTACCGTTTTCCTAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGATCTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
AAGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAGAAAATAGATACTGAGCTTTTTGTCAAAACG
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACTTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References