Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 698214..698860 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag M1781_RS03155 Protein ID WP_003403137.1
Coordinates 698214..698627 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag M1781_RS03160 Protein ID WP_003403139.1
Coordinates 698624..698860 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS03135 (M1781_03135) 694297..695847 + 1551 WP_003403119.1 MlaD family protein -
M1781_RS03140 (M1781_03140) 695899..696291 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
M1781_RS03145 (M1781_03145) 696288..696545 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
M1781_RS03150 (M1781_03150) 696728..697963 - 1236 WP_003403128.1 ATP-binding protein -
M1781_RS03155 (M1781_03155) 698214..698627 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS03160 (M1781_03160) 698624..698860 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 Antitoxin
M1781_RS03165 (M1781_03165) 698964..699470 - 507 WP_003900973.1 two component system sensor kinase HK1 -
M1781_RS03170 (M1781_03170) 699584..700114 - 531 WP_003917320.1 two component system sensor kinase HK2 -
M1781_RS03175 (M1781_03175) 700098..700793 - 696 WP_197044064.1 two-component system response regulator TcrA -
M1781_RS03180 (M1781_03180) 700916..701227 + 312 WP_003403164.1 hypothetical protein -
M1781_RS03185 (M1781_03185) 701299..702249 + 951 WP_003907436.1 DUF1259 domain-containing protein -
M1781_RS03190 (M1781_03190) 702490..703074 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
M1781_RS03195 (M1781_03195) 703076..703786 + 711 Protein_633 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T243735 WP_003403137.1 NZ_CP096843:c698627-698214 [Mycobacterium tuberculosis variant bovis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T243735 NZ_OX460960:c1437018-1436230 [Streptococcus agalactiae]
ATGAGATTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCTTTGCAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
AATCCCAGTTCAACCGAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGTGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTACGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAACTTCTA
AAGGTTACCAAGTTTCTTTAGCTATTATTGGTACCAAACCAGAACTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACGCAGGCCAGAGCAACACCCAAAGACCACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGAGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGATAGGGCTTGTATCTATGATTCTG
AAACGGATGAAGGTTCCGCAGCAGAAGTTCTACAAGACTGCCTCTTTGGAAAATGTAGTAAGGTTGAGGAAGAGATGATG
AAGTTAGGTCGGGAACGGTTAGTTAAACTGAATAATAAGAATTTGCTGGAGAGTAACTATGGAATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT243735 WP_003403139.1 NZ_CP096843:c698860-698624 [Mycobacterium tuberculosis variant bovis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT243735 NZ_OX460960:c1437494-1437018 [Streptococcus agalactiae]
ATGATTGGAGACAATATTAAATCACTACGCCGAACACACGATTTAACACAACCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTATGAAAATGGCACCAGCACCGTATCAACAGAGCTCATCGACCGCATTTGTCAGAAATTTA
ATGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAGAATATTGCTTTTGATGATGA
AGCCAATCCTTGGATTCTCATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGCTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ88

Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References