Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 695899..696545 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag M1781_RS03140 Protein ID WP_003403122.1
Coordinates 695899..696291 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag M1781_RS03145 Protein ID WP_003403125.1
Coordinates 696288..696545 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS03125 (M1781_03125) 691560..693087 + 1528 Protein_619 virulence factor Mce family protein -
M1781_RS03130 (M1781_03130) 693150..694292 + 1143 Protein_620 virulence factor Mce family protein -
M1781_RS03135 (M1781_03135) 694297..695847 + 1551 WP_003403119.1 MlaD family protein -
M1781_RS03140 (M1781_03140) 695899..696291 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
M1781_RS03145 (M1781_03145) 696288..696545 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
M1781_RS03150 (M1781_03150) 696728..697963 - 1236 WP_003403128.1 ATP-binding protein -
M1781_RS03155 (M1781_03155) 698214..698627 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
M1781_RS03160 (M1781_03160) 698624..698860 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
M1781_RS03165 (M1781_03165) 698964..699470 - 507 WP_003900973.1 two component system sensor kinase HK1 -
M1781_RS03170 (M1781_03170) 699584..700114 - 531 WP_003917320.1 two component system sensor kinase HK2 -
M1781_RS03175 (M1781_03175) 700098..700793 - 696 WP_197044064.1 two-component system response regulator TcrA -
M1781_RS03180 (M1781_03180) 700916..701227 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T243734 WP_003403122.1 NZ_CP096843:c696291-695899 [Mycobacterium tuberculosis variant bovis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T243734 NZ_OX460951:3267463-3267666 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACAGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT243734 WP_003403125.1 NZ_CP096843:c696545-696288 [Mycobacterium tuberculosis variant bovis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT243734 NZ_OX460951:3267041-3267400 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAAAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTGGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References