Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445150..446161 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag M1781_RS01945 Protein ID WP_003401859.1
Coordinates 445150..445743 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag M1781_RS01950 Protein ID WP_003401860.1
Coordinates 445772..446161 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS01925 (M1781_01925) 440799..442181 + 1383 WP_003898415.1 magnesium transporter -
M1781_RS01930 (M1781_01930) 442193..443227 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
M1781_RS01935 (M1781_01935) 443323..444006 + 684 WP_010950388.1 VTT domain-containing protein -
M1781_RS01940 (M1781_01940) 443995..445125 - 1131 WP_079293488.1 glycoside hydrolase family 76 protein -
M1781_RS01945 (M1781_01945) 445150..445743 - 594 WP_003401859.1 zeta toxin family protein Toxin
M1781_RS01950 (M1781_01950) 445772..446161 - 390 WP_003401860.1 hypothetical protein Antitoxin
M1781_RS01955 (M1781_01955) 446242..447453 - 1212 WP_010950389.1 VWA domain-containing protein -
M1781_RS01960 (M1781_01960) 447459..448061 - 603 WP_003898417.1 SRPBCC family protein -
M1781_RS01965 (M1781_01965) 448075..448971 - 897 WP_003401863.1 MoxR family ATPase -
M1781_RS01970 (M1781_01970) 448968..449561 - 594 WP_003401864.1 NTP transferase domain-containing protein -
M1781_RS01975 (M1781_01975) 449558..450313 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T243732 WP_003401859.1 NZ_CP096843:c445743-445150 [Mycobacterium tuberculosis variant bovis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T243732 NZ_OX460951:902597-902875 [Morganella morganii]
ATGATCAAATCATTCAAACACAAAGGGCTTAAGCAACTTTTTGAAAACGGTGTTATTTCAGGGATTCCGGCTCAGGATGC
TGTCAGAATTAATGATCGTTTGCAGGCTATTGATTCTGCAACCATGATTGAAGATTTAAATATTCATATTTATAAATTAC
ATCCCCTGCGGGGAGATCGGGTGGGTATCTGGTCAATAACAGTGAGAGCCAACTGGCGTATTACATTTGAGTTCAGAAAT
GGTGATGCGTATATTTTAAACTTGGAGGATTATCACTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT243732 WP_003401860.1 NZ_CP096843:c446161-445772 [Mycobacterium tuberculosis variant bovis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT243732 NZ_OX460951:902875-903195 [Morganella morganii]
ATGAAACAAGCTATTGTTTCACATCCCGGTACAATCGTAGCCAATATACTGACTGATCTGGGGGTGGGAGTCCGTCAGTT
TGCCGGAAATATCGGGGTAACACCGGCAACGGTTTCCCGGTTTTTATCCGGTAAAACAGCGCTGACCCCGGCATTGGCGA
TACGGATAGCGGCTGCGTTAGGCAGCAACCCGGCATTCTGGCTGCGCTTACAGGCAAATTATGATTTGCACCGCCTGGAA
AAGGAAATCGATATTTCGGGGATCAAGCTGTACGGTGCTTCTGAAGAAGATGGTTTTTGTAATAGATCACCGGATAAATA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References