Detailed information of TA system TA243727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3781082..3781767
• Replicon: chromosome
• Accession: NZ_CP096842
• Organism: Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: M1772_RS17755
• Protein ID: WP_003417998.1
• Coordinates: 3781357..3781767 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: M1772_RS17750
• Protein ID: WP_003912220.1
• Coordinates: 3781082..3781360 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1772_RS17730 (M1772_17720)	3777071..3778672	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
M1772_RS17735 (M1772_17725)	3778689..3779393	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
M1772_RS17740 (M1772_17730)	3779511..3780077	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
M1772_RS17745 (M1772_17735)	3780139..3781026	+	888	WP_069523316.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
M1772_RS17750 (M1772_17740)	3781082..3781360	+	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1772_RS17755 (M1772_17745)	3781357..3781767	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1772_RS17760 (M1772_17750)	3781800..3783536	-	1737	WP_003418002.1	cholesterol oxidase	-
M1772_RS17765 (M1772_17755)	3783592..3784719	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
M1772_RS17770 (M1772_17760)	3784739..3786328	-	1590	WP_003900682.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T243727 WP_003417998.1 NZ_CP096842:3781357-3781767 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T243727 NZ_OX460942:c1905628-1905374 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT243727 WP_003912220.1 NZ_CP096842:3781082-3781360 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT243727 NZ_OX460942:c1905887-1905621 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Structures

Toxin

• AlphaFold DB: G0TIR9