243726

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3727069..3727598 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag M1772_RS17520 Protein ID WP_003417760.1
Coordinates 3727341..3727598 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag M1772_RS17515 Protein ID WP_003417757.1
Coordinates 3727069..3727344 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS17480 (M1772_17470) 3723642..3724331 - 690 WP_273590116.1 BBE domain-containing protein -
M1772_RS17485 (M1772_17475) 3724518..3724889 - 372 WP_003417739.1 FAD-binding protein -
M1772_RS17490 (M1772_17480) 3724787..3725005 - 219 WP_157132559.1 hypothetical protein -
M1772_RS17495 (M1772_17485) 3725032..3725292 - 261 WP_003417741.1 hypothetical protein -
M1772_RS17500 (M1772_17490) 3725407..3725796 + 390 WP_010950876.1 DUF732 domain-containing protein -
M1772_RS17505 (M1772_17495) 3725810..3726103 - 294 WP_003417749.1 DUF3017 domain-containing protein -
M1772_RS17510 (M1772_17500) 3726100..3726945 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
M1772_RS17515 (M1772_17505) 3727069..3727344 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
M1772_RS17520 (M1772_17510) 3727341..3727598 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
M1772_RS17525 (M1772_17515) 3727640..3728830 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
M1772_RS17530 (M1772_17520) 3728947..3729315 + 369 WP_003417765.1 FHA domain-containing protein -
M1772_RS17535 (M1772_17525) 3729312..3729863 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
M1772_RS17540 (M1772_17530) 3729870..3730451 - 582 WP_003417769.1 ATP/GTP-binding protein -
M1772_RS17545 (M1772_17535) 3730432..3730800 - 369 WP_003417772.1 DUF742 domain-containing protein -
M1772_RS17550 (M1772_17540) 3730778..3731170 - 393 WP_011799344.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T243726 WP_003417760.1 NZ_CP096842:3727341-3727598 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T243726 NZ_OX460941:1326127-1326972 [Streptococcus agalactiae]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCTAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTAGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATTGGAGTTGAATCTCGTAGTACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTCTCAGAAGAT
ACTGTGGAGCAGCAACTCAAGGAAATTTTAGCAGATTCAGAAGAAGGTATATCTTTTGTGATTCAATCCATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTTGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAGAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGCAGAAG
CAAAGATTTTTATGATGTTTATATTCTATCAAAACTAAAGAAAGAAGACATTGACTTCATTCAATTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAGCTCGATTTTGAAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACACT
ATTCAGAATAAACAATGGCAAAATTATTCGAAAAAATATAGCTATACAAAGGGGATTTCCCTTACAGATGTTCTTGATGA
GATGATTCATCTCATAGCAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT243726 WP_003417757.1 NZ_CP096842:3727069-3727344 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT243726 NZ_OX460941:1325540-1326130 [Streptococcus agalactiae]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGAATTATATACCGCGTCGAGAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTTCTTCTTTCAGTACCGATATCCCAAGGCTGTTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACATAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCTAA
TCTGAACATTCATTCCGTTTCTAAGAAATATAGCGAATTAGGAATTACTCTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGTCTATGATTTCGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACTTTACGGAAACTATCCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References