243718

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3029135..3029822 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID G0TF65
Locus tag M1772_RS14360 Protein ID WP_003414064.1
Coordinates 3029427..3029822 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag M1772_RS14355 Protein ID WP_003414061.1
Coordinates 3029135..3029401 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS14330 (M1772_14320) 3024774..3025676 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
M1772_RS14335 (M1772_14325) 3025745..3026497 - 753 WP_069523501.1 FAD-dependent thymidylate synthase -
M1772_RS14340 (M1772_14335) 3026741..3027016 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
M1772_RS14345 (M1772_14340) 3027013..3028635 - 1623 WP_003414057.1 class I SAM-dependent DNA methyltransferase -
M1772_RS14350 (M1772_14345) 3028722..3029138 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 -
M1772_RS14355 (M1772_14350) 3029135..3029401 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1772_RS14360 (M1772_14355) 3029427..3029822 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin Toxin
M1772_RS14365 (M1772_14360) 3029819..3030088 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
M1772_RS14370 (M1772_14365) 3030098..3031192 - 1095 WP_003414068.1 restriction endonuclease subunit S -
M1772_RS14375 (M1772_14370) 3031189..3031608 - 420 Protein_2836 winged helix-turn-helix domain-containing protein -
M1772_RS14380 (M1772_14375) 3031607..3031681 + 75 Protein_2837 hypothetical protein -
M1772_RS14385 (M1772_14380) 3031682..3032161 - 480 WP_003414073.1 dihydrofolate reductase -
M1772_RS14390 (M1772_14385) 3032232..3033032 - 801 WP_003911953.1 thymidylate synthase -
M1772_RS14395 (M1772_14390) 3033188..3033925 + 738 WP_011799288.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14340.04 Da        Isoelectric Point: 4.7145

>T243718 WP_003414064.1 NZ_CP096842:c3029822-3029427 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT

Download         Length: 396 bp

>T243718 NZ_OX460935:1317836-1318672 [Streptococcus agalactiae]
GTGAACAAAGCAAAATTAACGGCGCTCTGCCATAAAGTTTCAAAAGAAACAGGATTAACGTTTAATTCTGTGATGACCTA
CTACTTTCTGGAAATTATTCTGAAAAAATTGAGCCAAAGCGCTTATGCTCAAAATTACATTTTCAAAGGAGGTTTTCTGC
TCTCAAATGTCGTCGGGGTTGCTTCCCGTAGTACCGTTGACATTGACTTTCTCTTTAGTAAAATGAATCTATCAGAAGAG
ACCGTGCATCAGCAATTGGAGGATATCCTTGGAAAATCTGATGAAGATATTTCTTTCACTATTCAGTCGGTCACAGCAAT
TAAGGAAAGTGATGATTATGGAGGATATCGTGCAAGTATCCTTTGCCAGCTTGAGAACATCAGACAAGTCATCCACCTGG
ATATCGCAACTGGGGACATTGTCACTCCGCAGCCCATCACTTACGATTACAAGCCAATCTTCACATCAGAACAGTTTCCT
ATCATTGCCTACACGATTGAGACTATCTTAGCAGAGAAACTACAAACTATTTATTCTCGCAGCTTCTTGAATAGTCGAAG
CAAAGACTTCTATGACATCTATATCTTGTCAAAATTGAAGAAATCAGAAATTGATTCGCAACAACTTCTCACTGCTTGTC
AGCGTACCTTCGATTATCGAGGTACTGAATTAGACTTCGATAAATTCATCAATCTGCTAGAAACATTCAAAACAGATTCA
ACCCAAAACCATCAGTGGGAAAACTACTCTAAAAAGTATAGTTACACTAAAGGTATTACATTTAACGATGTTCTGACAGA
GATGACTGATTTGCTTGTAACTATCAAAAATCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT243718 WP_003414061.1 NZ_CP096842:c3029401-3029135 [Mycobacterium tuberculosis variant bovis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp

>AT243718 NZ_OX460935:1317249-1317839 [Streptococcus agalactiae]
ATGTCTAATAAAGAAACCGTTCTGAATTATCTCAAACAAAATAACGGTATCATTACATATAAAGACTGTAAAGAGCTTGG
GGTTCCAGCTGTCTATCTCTCACGACTTGAAAATGAAGAGAAAATATTCCGAGTGGACAAGGGCATCTATCTTTCTACCG
ATGGTGACTATGACGAGTACTACTTCTTCCAATACAGATTTTCAAGAGCTATTTACTCCTATGTTTCCGCTCTTTATCTT
CAAGGGTTCACGGATGAAATCCCTCAATATTTTGAAGTCACCGTACCAAGAGGGTATCGTTTCAATAATCCGCCTCAAAA
CCTTGCGGTTCATACCGTCCCAAAGGAAATTGTTGACCTTGGTATTATCTCTATAAAGACACCCTGGGGACAGACCGTTA
AGACCTACGACTTTGAGCGTATCATCTGTGACTTTATTCAAAATCGTAAAAAAATTGATAATGAACTTTTCGTCAAAACT
CTTAAGGCTTATGTCAACTATCCAAATAAAAACCTGACAAACCTTTACCAATATGCTGAAAAAATGAAAATTATCAATCA
AACAAAACAAACACTTGAGGTGCTAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TF65

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References