243716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2899565..2900279 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag M1772_RS13600 Protein ID WP_003413460.1
Coordinates 2899839..2900279 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag M1772_RS13595 Protein ID WP_003413456.1
Coordinates 2899565..2899852 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS13560 (M1772_13550) 2894987..2895232 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M1772_RS13565 (M1772_13555) 2895229..2895633 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
M1772_RS13570 (M1772_13560) 2895850..2896470 + 621 WP_003413441.1 DUF4178 domain-containing protein -
M1772_RS13575 (M1772_13565) 2896481..2896975 + 495 WP_003413444.1 DUF2617 family protein -
M1772_RS13580 (M1772_13570) 2896972..2897403 + 432 WP_003413445.1 DUF4247 domain-containing protein -
M1772_RS13585 (M1772_13575) 2897428..2897886 + 459 WP_003413451.1 DUF350 domain-containing protein -
M1772_RS13590 (M1772_13580) 2897883..2899454 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
M1772_RS13595 (M1772_13585) 2899565..2899852 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
M1772_RS13600 (M1772_13590) 2899839..2900279 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
M1772_RS13605 (M1772_13595) 2900300..2901055 - 756 WP_183078525.1 YebC/PmpR family DNA-binding transcriptional regulator -
M1772_RS13610 (M1772_13600) 2901188..2901784 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
M1772_RS13615 (M1772_13605) 2901792..2902637 - 846 WP_010950749.1 acyl-CoA thioesterase II -
M1772_RS13620 (M1772_13610) 2902666..2903565 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
M1772_RS13625 (M1772_13615) 2903693..2904367 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T243716 WP_003413460.1 NZ_CP096842:2899839-2900279 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T243716 NZ_OX460934:1394776-1395621 [Streptococcus agalactiae]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTTTAGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTACTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATTGGAGTTGAATCTCGTAGCACAGTTGATATTGATTTTTTGTTCCATCAAATGACACTTTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAGTCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGCATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT243716 WP_003413456.1 NZ_CP096842:2899565-2899852 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT243716 NZ_OX460934:1394189-1394779 [Streptococcus agalactiae]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGAATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGATATCCCAAGGCTGTTTTCTCATATATCTCAGCGCTTTACCTC
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCGAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGTGTATGATTTTGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATCCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References