243715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2839218..2839855 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag M1772_RS13335 Protein ID WP_003413180.1
Coordinates 2839218..2839613 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag M1772_RS13340 Protein ID WP_003413183.1
Coordinates 2839610..2839855 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS13295 (M1772_13285) 2835303..2835962 + 660 WP_003900846.1 LppA family lipoprotein -
M1772_RS13300 (M1772_13290) 2835959..2836618 + 660 WP_003900847.1 LppA family lipoprotein -
M1772_RS13305 (M1772_13295) 2836615..2837277 + 663 WP_003900848.1 LppA family lipoprotein -
M1772_RS13310 (M1772_13300) 2837274..2837552 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
M1772_RS13315 (M1772_13305) 2837645..2838058 + 414 WP_003413164.1 PIN domain nuclease -
M1772_RS13320 (M1772_13310) 2838097..2838354 + 258 WP_003413167.1 CopG family transcriptional regulator -
M1772_RS13325 (M1772_13315) 2838351..2838728 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
M1772_RS13330 (M1772_13320) 2838744..2839118 - 375 WP_003413177.1 hypothetical protein -
M1772_RS13335 (M1772_13325) 2839218..2839613 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
M1772_RS13340 (M1772_13330) 2839610..2839855 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
M1772_RS13345 (M1772_13335) 2840266..2840685 - 420 WP_003413190.1 A24 family peptidase -
M1772_RS13350 (M1772_13340) 2840697..2841505 - 809 Protein_2635 shikimate dehydrogenase -
M1772_RS13355 (M1772_13345) 2841502..2842755 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
M1772_RS13360 (M1772_13350) 2842748..2843260 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T243715 WP_003413180.1 NZ_CP096842:c2839613-2839218 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T243715 NZ_OX460934:c1374496-1373702 [Streptococcus agalactiae]
ATGAGATTGGAAGAATTTAGTAAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCTTTAACCAGAGGAAAGAC
GATTCCAGATCGACCGAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGAAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAAATTGCTCAATTATTAGCTTCTA
AAGGATATCAGATTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACTCTGATTCGTTATGAAGAG
CTTTATGCCATAGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGATTGTATTCAGATTTATCAAAGGGATAGGACTTGTATCTATAATTCTG
AAACAGATGAAGGTTCCGCAGCAGAAGTGCTACAAGAGTGTCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGATG
AAGGCAGGACAGGAACGGTTGAGGGAGTTGTGTAATAGAGATAGAGAGGAAAAGTTTGAAAAAAATAAAAGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT243715 WP_003413183.1 NZ_CP096842:c2839855-2839610 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT243715 NZ_OX460934:c1374972-1374496 [Streptococcus agalactiae]
ATGATTGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTACAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATCAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCATAATATTGCTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATTGAGCGGATATTAGACATGGTGTATCATCGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References