243714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2838097..2838728 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag M1772_RS13325 Protein ID WP_003413174.1
Coordinates 2838351..2838728 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag M1772_RS13320 Protein ID WP_003413167.1
Coordinates 2838097..2838354 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS13285 (M1772_13275) 2833355..2833669 + 315 WP_009937839.1 hypothetical protein -
M1772_RS13290 (M1772_13280) 2833965..2835176 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
M1772_RS13295 (M1772_13285) 2835303..2835962 + 660 WP_003900846.1 LppA family lipoprotein -
M1772_RS13300 (M1772_13290) 2835959..2836618 + 660 WP_003900847.1 LppA family lipoprotein -
M1772_RS13305 (M1772_13295) 2836615..2837277 + 663 WP_003900848.1 LppA family lipoprotein -
M1772_RS13310 (M1772_13300) 2837274..2837552 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
M1772_RS13315 (M1772_13305) 2837645..2838058 + 414 WP_003413164.1 PIN domain nuclease -
M1772_RS13320 (M1772_13310) 2838097..2838354 + 258 WP_003413167.1 CopG family transcriptional regulator Antitoxin
M1772_RS13325 (M1772_13315) 2838351..2838728 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
M1772_RS13330 (M1772_13320) 2838744..2839118 - 375 WP_003413177.1 hypothetical protein -
M1772_RS13335 (M1772_13325) 2839218..2839613 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
M1772_RS13340 (M1772_13330) 2839610..2839855 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
M1772_RS13345 (M1772_13335) 2840266..2840685 - 420 WP_003413190.1 A24 family peptidase -
M1772_RS13350 (M1772_13340) 2840697..2841505 - 809 Protein_2635 shikimate dehydrogenase -
M1772_RS13355 (M1772_13345) 2841502..2842755 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
M1772_RS13360 (M1772_13350) 2842748..2843260 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T243714 WP_003413174.1 NZ_CP096842:2838351-2838728 [Mycobacterium tuberculosis variant bovis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T243714 NZ_OX460934:1108038-1108883 [Streptococcus agalactiae]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTTTAGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTACTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATTGGAGTTGAATCTCGTAGCACAGTTGATATTGATTTTTTGTTCCATCAAATGACACTTTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAGTCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGCATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT243714 WP_003413167.1 NZ_CP096842:2838097-2838354 [Mycobacterium tuberculosis variant bovis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT243714 NZ_OX460934:1107451-1108041 [Streptococcus agalactiae]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGAACTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGATATCCCAAGGCTGTCTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCGAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGTGTATGATTTTGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATCCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References