243710

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2387277..2387806 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag M1772_RS11180 Protein ID WP_003411124.1
Coordinates 2387277..2387594 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag M1772_RS11185 Protein ID WP_003411127.1
Coordinates 2387591..2387806 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS11150 (M1772_11145) 2382298..2383374 + 1077 WP_069523391.1 hypothetical protein -
M1772_RS11155 (M1772_11150) 2383371..2383652 + 282 WP_019283661.1 DUF5703 family protein -
M1772_RS11160 (M1772_11155) 2383688..2384761 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
M1772_RS11165 (M1772_11160) 2384766..2385296 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
M1772_RS11170 (M1772_11165) 2385344..2386690 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
M1772_RS11180 (M1772_11175) 2387277..2387594 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1772_RS11185 (M1772_11180) 2387591..2387806 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
M1772_RS11190 (M1772_11185) 2388061..2389119 + 1059 WP_273590101.1 phosphoribosyltransferase family protein -
M1772_RS11195 (M1772_11190) 2389249..2389605 - 357 WP_003411130.1 hypothetical protein -
M1772_RS11200 (M1772_11195) 2389700..2390482 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
M1772_RS11205 (M1772_11200) 2390750..2391040 - 291 WP_003900476.1 YggT family protein -
M1772_RS11210 (M1772_11205) 2391202..2391858 - 657 WP_003411133.1 cell division protein SepF -
M1772_RS11215 (M1772_11210) 2391924..2392700 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T243710 WP_003411124.1 NZ_CP096842:c2387594-2387277 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T243710 NZ_OX460931:c1205484-1204690 [Streptococcus agalactiae]
ATGAGATTGGAAGAATTTAGTAAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCTTTAACCAGAGGAAAGAC
GATTCCAGATCGACCGAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGAAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAAATTGCTCAATTATTAGCTTCTA
AAGGATATCAGATTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACTCTGATTCGTTATGAAGAG
CTTTATGCCATAGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGATTGTATTCAGATTTATCAAAGGGATAGGACTTGTATCTATAATTCTG
AAACAGATGAAGGTTCCGCAGCAGAAGTGCTACAAGAGTGTCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGATG
AAGGCAGGACAGGAACGGTTGAGGGAGTTGTGTAATAGAGATAGAGAGGAAAAGTTTGAAAAAAATAAAAGCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT243710 WP_003411127.1 NZ_CP096842:c2387806-2387591 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT243710 NZ_OX460931:c1205960-1205484 [Streptococcus agalactiae]
ATGATTGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTACAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATCAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCATAATATTGCTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTTGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATTGAGCGGATATTAGACATGGTGTATCATCGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References