243708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2309312..2309948 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag M1772_RS10790 Protein ID WP_003410654.1
Coordinates 2309538..2309948 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag M1772_RS10785 Protein ID WP_003410651.1
Coordinates 2309312..2309545 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS10770 (M1772_10765) 2304769..2305161 + 393 WP_229303073.1 metal ABC transporter permease -
M1772_RS10775 (M1772_10770) 2305162..2305566 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
M1772_RS10780 (M1772_10775) 2305650..2309234 - 3585 WP_010950652.1 cobaltochelatase subunit CobN -
M1772_RS10785 (M1772_10780) 2309312..2309545 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
M1772_RS10790 (M1772_10785) 2309538..2309948 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
M1772_RS10795 (M1772_10790) 2309932..2311023 + 1092 WP_273590099.1 precorrin-3B synthase -
M1772_RS10800 (M1772_10795) 2311033..2311659 + 627 WP_003410658.1 precorrin-8X methylmutase -
M1772_RS10805 (M1772_10800) 2311656..2313182 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
M1772_RS10810 (M1772_10805) 2313128..2314351 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T243708 WP_003410654.1 NZ_CP096842:2309538-2309948 [Mycobacterium tuberculosis variant bovis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T243708 NZ_OX460910:c1032297-1032046 [Photobacterium phosphoreum]
ATGCGTATAGTTTCTTTTACTGAAGCTCGAAATGGCCTTAAATCTGTTCTTGATGGCGTAGTTAATGATGCAGATTGCAC
AATTATCACTCGTCGAGATTCTGAAGATGCAGTTGTAATGTCTATGGATTATTATAATAGCTTAATGGAAACGATTTATT
TATCTCGTTCTCCTGCTAATGCTGCTCATCTAAACAAATCAATTGCTCAATACAATGCCGGTCAAACTACGGAAAGAGAT
TTACTTGAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT243708 WP_003410651.1 NZ_CP096842:2309312-2309545 [Mycobacterium tuberculosis variant bovis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT243708 NZ_OX460910:c1032049-1031789 [Photobacterium phosphoreum]
ATGAGTCGAATGTTAGCTTGGACTGACGATGCTTGGGATGATTACTTGTATTGGCAAGGTCAGGATAAGAAAACGCTGAA
GCGCATCAATAAATTAATTACTGATACGAAGCGTTCTCCCTTCGAAGGCATTGGTAAACCAGAACCATTGAAAGAAAATT
TGGCAGGTTTTTGGTCACGTAGAATTGATGATACCAACCGATTAGTTTATGTAGTTAATGATGCACATTTGACAATAATT
TCCTGTCGCTATCATTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV50

References