243706

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2241526..2242152 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag M1772_RS10500 Protein ID WP_003410075.1
Coordinates 2241754..2242152 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1772_RS10495 Protein ID WP_019283586.1
Coordinates 2241526..2241753 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS10485 (M1772_10480) 2239565..2239909 - 345 WP_003410065.1 ferredoxin family protein -
M1772_RS10490 (M1772_10485) 2240098..2241267 - 1170 WP_003899126.1 ATP-binding protein -
M1772_RS10495 (M1772_10490) 2241526..2241753 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1772_RS10500 (M1772_10495) 2241754..2242152 + 399 WP_003410075.1 PIN domain nuclease Toxin
M1772_RS10505 (M1772_10500) 2242335..2242766 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
M1772_RS10510 (M1772_10505) 2242867..2243301 + 435 WP_003914358.1 DUF1398 domain-containing protein -
M1772_RS10515 (M1772_10510) 2243738..2243917 - 180 Protein_2078 hypothetical protein -
M1772_RS10520 (M1772_10515) 2244005..2244625 + 621 WP_003410086.1 IS110 family transposase -
M1772_RS10525 (M1772_10520) 2244579..2245169 + 591 WP_003899131.1 IS110 family transposase -
M1772_RS10530 (M1772_10525) 2245297..2246553 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T243706 WP_003410075.1 NZ_CP096842:2241754-2242152 [Mycobacterium tuberculosis variant bovis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T243706 NZ_OX460910:360304-361245 [Photobacterium phosphoreum]
ATGAATAAACTGAAACAGCAGTTTCTTGAGGTTTCCGATGCCTTAGCGCTCGGAAACCCAGCCATAATTGAGAAAGACTA
TTGGGTTGTGGCACTACTAGCACAACTTGAAAAACTCATCATAGATTCTCATCAACTGGTTTTTTCTGGCGGAACGGCAT
TGGCAAAATCCAATGTGAAGATCATGCGTATGTCTGAAGATGTCGATATCAAGCTGATCCCTAATGCCGACTTTCATACA
TTAAGCAGAAGTAAGAAAAAAATCGTTCGTAAATCATTGCTTGAGACACTTGAAAAATCGATTAGGGAATCAAATACCTT
TTTGATTGAAAACAAACAAGCATGGGACGAATACCGTTATGTGGAATATGACTTAAAATATCCACAACAGTTTAGTCAGG
CACCTTGTTTACGCCCCATTATCAAACTTGAATTAATGGAGACCATTCCATTACAAGAAACAGAGCAGCGAAGCATACAA
TCATTAGTGGCTGAACTTTACCAACACACGAAAGAAGTTAAAGCATTTGCTTGTATATCTGTTCATGCCACCTTGGTTGA
AAAGATTATTTCAATGCTTCGCCGTACCATGTTAGCTAAACGTGATGAAAATCGTAAAGATGATCAAACATTAGTTCGTC
ATATCTACGATGTTTACTGCATAGACAAAGCACAACAAGTTGATATCAAATCATTATCACTACTCTTTAACGCAGTATTG
CAAGAAGATATCACTCGCTTTGGTAATCAACATACTGAATTTGTAAATAATCCTTCTAAAGAGCTACAAGATGGCTTATC
AGAACTAGAAAATAATCCACTTTATCGCCAACGCTTTGATGCTTTTGTAACACCGATGGTTTTTAACCAACAACCACACG
ATTTTGATAGCTGCTTTGCCTCATTTAAGCGCATTGCTGAACTACTAATTAAAACAATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT243706 WP_019283586.1 NZ_CP096842:2241526-2241753 [Mycobacterium tuberculosis variant bovis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT243706 NZ_OX460910:359897-360301 [Photobacterium phosphoreum]
ATGACTACAACTGATCGTATTTATCAAAAGATAAAACGTTCAAGACGTTATGTTTTTGAACGTAAAAACTTTGAAGGTGT
GGCTTGTTATGATCAAGTCGGTCGCGCTTTGAAACAATTAGTAAATCAAGGCGAATTAATGAAAATCGGCTATGGCCTTT
ACACCAAATCACGAATGAATAGTTTAACGGGTAAGCCAATGCCAACTCATCCAGGTGGGACGGACGCGCTTATGCGAGAA
ATCCTTAAGATGAAAGGCGTAGACTTTGAGATAGATAGTCTGTCTCTTCAAAGCTTATCGGGTGAAAACACTCAAATCCC
TTCATCCATTAATTACTCATGGAACTCAAAACAGTTTAATCGAAAACTGGTAGTGGGTAGCCGTGTCATACACTCTCCAA
ATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References