243705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2217786..2218372 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag M1772_RS10395 Protein ID WP_003410010.1
Coordinates 2217786..2218130 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag M1772_RS10400 Protein ID WP_003410014.1
Coordinates 2218124..2218372 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS10360 (M1772_10355) 2213492..2214091 + 600 WP_003409989.1 L-lysine exporter -
M1772_RS10365 (M1772_10360) 2214507..2214935 + 429 WP_003409992.1 cellulose-binding protein -
M1772_RS10370 (M1772_10365) 2215161..2215700 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1772_RS10375 (M1772_10370) 2216220..2216780 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
M1772_RS10380 (M1772_10375) 2216777..2217118 - 342 WP_003410003.1 DUF2384 domain-containing protein -
M1772_RS10385 (M1772_10380) 2217204..2217461 + 258 WP_003410006.1 hypothetical protein -
M1772_RS10390 (M1772_10385) 2217362..2217697 - 336 WP_003410009.1 dehydrogenase -
M1772_RS10395 (M1772_10390) 2217786..2218130 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
M1772_RS10400 (M1772_10395) 2218124..2218372 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
M1772_RS10405 (M1772_10400) 2218472..2220787 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1772_RS10410 (M1772_10405) 2220784..2221056 - 273 WP_003410017.1 DUF1490 family protein -
M1772_RS10415 (M1772_10410) 2221109..2221465 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
M1772_RS10420 (M1772_10415) 2221622..2222389 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T243705 WP_003410010.1 NZ_CP096842:c2218130-2217786 [Mycobacterium tuberculosis variant bovis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T243705 NZ_OX460909:1817775-1818059 [Photobacterium phosphoreum]
ATGACTTATAAGTTAGATTTCAAAAAGAGCGCATATAAAGAATGGAATAAACTTGGTGCAACGCTTCGTGAACAATTTAA
GAAAAAACTATTAGAACGCTTAGATAATCCTCACGTTCCTGCGTCAAAGCTATCAGGCGCTGATAATTTATACAAAATTA
AGCTACAACAGTCTGGTTACCGATTAGTATACAAAGTTGAAGATGACGTAATAATTGTCACCGTTTTAGCTGTTGGCAAA
AGAGAACGCAGCGACGTATACAAAAAAGCGATGCACAGGATTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT243705 WP_003410014.1 NZ_CP096842:c2218372-2218124 [Mycobacterium tuberculosis variant bovis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT243705 NZ_OX460909:1817537-1817785 [Photobacterium phosphoreum]
ATGACTACTAGAATTTTAGCTGATGTTGCAGCAAGCATTACCGAGTTTAAAGCTAACCCAATGAAAGTTGCTTCAAGTGC
TTATGGCGAGGCTGTTGCTGTACTAAACAGAAATGAGCCTGCATTTTATTGTGTACCAGCAGAAGCTTATGAACTATTGA
TGGATCGAATTGAAGACCTCGAACTATTATCTCTTGCCGCAGAACGAGAGAATGAAGAAACTATTTCGGTAGACATCCAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References