243703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2208894..2209582 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag M1772_RS10330 Protein ID WP_003409958.1
Coordinates 2208894..2209313 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag M1772_RS10335 Protein ID WP_003409968.1
Coordinates 2209322..2209582 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS10300 (M1772_10295) 2203900..2204205 + 306 Protein_2035 ABC transporter permease -
M1772_RS10305 (M1772_10300) 2204201..2204281 + 81 Protein_2036 hypothetical protein -
M1772_RS10310 (M1772_10305) 2204389..2205237 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
M1772_RS10315 (M1772_10310) 2205200..2206645 - 1446 WP_183078488.1 APC family permease -
M1772_RS10320 (M1772_10315) 2206824..2207510 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
M1772_RS10325 (M1772_10320) 2207701..2208669 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
M1772_RS10330 (M1772_10325) 2208894..2209313 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
M1772_RS10335 (M1772_10330) 2209322..2209582 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1772_RS10340 (M1772_10335) 2209725..2211401 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
M1772_RS10345 (M1772_10340) 2211389..2212042 - 654 WP_003409976.1 cutinase Cfp21 -
M1772_RS10350 (M1772_10345) 2212157..2212387 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1772_RS10355 (M1772_10350) 2212472..2213383 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1772_RS10360 (M1772_10355) 2213492..2214091 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T243703 WP_003409958.1 NZ_CP096842:c2209313-2208894 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T243703 NZ_OX460909:1813240-1813746 [Photobacterium phosphoreum]
ATAATGAACACTGTCCAATCAGAAAAAGCCAAGCATGACCGAAATCGTTTTGATTGTGGTATTACCGCACTCAATAATTA
CTTAAAAGTTATGGCAAGCCAACAAGCTAAGAAAGACAATACTCGTACTTTTGTTCTTGAAGATAAGCAATATCCTGAGC
ACATTATTGGTTATTACACATTAACAATGACACCCATTGATATTCAGGATTTACCTCCTAAATTACAGAAGAAGCATCAC
AGTGTAACTTCTGGTGGTTTGATTGCCCGCTTAGCCGTTGACCATAGATACAAAGGTCAGGGTTTCGGTGAGTGGCTTTT
GATTGATGCGCTTAGAAAACTATTAATGGCAAGTGAAACGGTCGCCTTCCCTGTCGTCATTGTTGATGCAAAAGATGGCG
CTGAGGATTTCTATGAAAAATACGGTTTTACCGCATTTAAAGACGCTGATAACAAACTATTTATTACAATTGCAGATATT
AGAGCTAGTATCGGTGAATTAATTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT243703 WP_003409968.1 NZ_CP096842:c2209582-2209322 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT243703 NZ_OX460909:1812971-1813243 [Photobacterium phosphoreum]
ATGGCTACTGCATTACCTCGTATTACAGCACGTGTAGATATTGATACACAAGAACTACTATCTCAAGCTGCGGCTATTGC
CGGTATGTCTAGCATTAACTCATTTGTGCTTAGTGCAGCTATAGAAAAAGCAAAAACTATTATGGAACGTGAACGAGCCC
TACAACTAAGCCAGCAAGATGCTATGACTTTAATGACTGCGTTAGACCAACCAGCTAAACCAAATAACAAATTACAAAAA
GCCGCTTCACGTTATATGGATAAAACTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References