Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2199880..2200424 | Replicon | chromosome |
| Accession | NZ_CP096842 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb3114 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | M1772_RS10270 | Protein ID | WP_003409896.1 |
| Coordinates | 2199880..2200176 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | M1772_RS10275 | Protein ID | WP_003409899.1 |
| Coordinates | 2200173..2200424 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1772_RS10215 (M1772_10210) | 2194913..2195263 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1772_RS10220 (M1772_10215) | 2195274..2196176 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| M1772_RS10225 (M1772_10220) | 2196197..2196388 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1772_RS10230 (M1772_10225) | 2196389..2196685 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1772_RS10235 (M1772_10230) | 2196925..2197140 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1772_RS10240 (M1772_10235) | 2197137..2197448 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1772_RS10245 (M1772_10240) | 2197422..2197943 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1772_RS10250 (M1772_10245) | 2197918..2198295 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| M1772_RS10255 (M1772_10250) | 2198337..2198786 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| M1772_RS10260 (M1772_10255) | 2198783..2199328 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1772_RS10265 (M1772_10260) | 2199217..2199831 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1772_RS10270 (M1772_10265) | 2199880..2200176 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1772_RS10275 (M1772_10270) | 2200173..2200424 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| M1772_RS10280 (M1772_10275) | 2200411..2200905 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1772_RS10285 (M1772_10280) | 2201065..2201472 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1772_RS10290 (M1772_10285) | 2201476..2201748 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1772_RS10295 (M1772_10290) | 2201781..2203001 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| M1772_RS10300 (M1772_10295) | 2203900..2204205 | + | 306 | Protein_2035 | ABC transporter permease | - |
| M1772_RS10305 (M1772_10300) | 2204201..2204281 | + | 81 | Protein_2036 | hypothetical protein | - |
| M1772_RS10310 (M1772_10305) | 2204389..2205237 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T243702 WP_003409896.1 NZ_CP096842:c2200176-2199880 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T243702 NZ_OX460909:c502874-502527 [Photobacterium phosphoreum]
ATGTGGACAGTCATTACGACAGATTTTTTTGATGAATGGTTTGATGCTCAATCTGACGATACGCAAGAAAAAGTATTAGC
TGGTTTAGTTGCATTACAAACAGGAGGGCCAACAATCGGTCGCCCTCTTGTTGATACAGTAAATGCATCGAAATATAACA
ATATGAAAGAGCTTAGAGTCCAACATCGAGGGGATCCTATAAGAGCTTTCTTTGCTTTCGATCCTTTACGTCAGGCAATT
GTACTTTGTGCCGGTAACAAAGGTGGAAATGAAAAACGTTTTTACAAACAAATGATCCCTATTGCTGATTTTGAGTTTGC
TAAACATCTTGAAGAATTGGAGAAATAA
ATGTGGACAGTCATTACGACAGATTTTTTTGATGAATGGTTTGATGCTCAATCTGACGATACGCAAGAAAAAGTATTAGC
TGGTTTAGTTGCATTACAAACAGGAGGGCCAACAATCGGTCGCCCTCTTGTTGATACAGTAAATGCATCGAAATATAACA
ATATGAAAGAGCTTAGAGTCCAACATCGAGGGGATCCTATAAGAGCTTTCTTTGCTTTCGATCCTTTACGTCAGGCAATT
GTACTTTGTGCCGGTAACAAAGGTGGAAATGAAAAACGTTTTTACAAACAAATGATCCCTATTGCTGATTTTGAGTTTGC
TAAACATCTTGAAGAATTGGAGAAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT243702 WP_003409899.1 NZ_CP096842:c2200424-2200173 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT243702 NZ_OX460909:c502524-502222 [Photobacterium phosphoreum]
ATGGCTAGAAATTTAAATGATATGTTGGCTTCTCGTTCTCAAGATAGTCAGCATCGAATTGCTGAAATGGCGGACGAAAT
GTTACTCGAAGTTAAGTTCCAAGCTATTCGTGAAGAACTAGAACTAACTCAAGCTGAATTGGCTAGAAATATGGGGATTA
GTCAGCCGTCTGTTGTTGCAATAGAGCAGCGTGGTAATGATGTAAAGCTATCAACGATTAAGCGTTATATTGAGGCTATG
GGCGGCAAAATGAGTATCAATATTGAATTACCAACAGGTAAACATGTTGGGTTTAACGTCTAA
ATGGCTAGAAATTTAAATGATATGTTGGCTTCTCGTTCTCAAGATAGTCAGCATCGAATTGCTGAAATGGCGGACGAAAT
GTTACTCGAAGTTAAGTTCCAAGCTATTCGTGAAGAACTAGAACTAACTCAAGCTGAATTGGCTAGAAATATGGGGATTA
GTCAGCCGTCTGTTGTTGCAATAGAGCAGCGTGGTAATGATGTAAAGCTATCAACGATTAAGCGTTATATTGAGGCTATG
GGCGGCAAAATGAGTATCAATATTGAATTACCAACAGGTAAACATGTTGGGTTTAACGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |