243699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1957913..1958373 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag M1772_RS09170 Protein ID WP_003408531.1
Coordinates 1958125..1958373 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag M1772_RS09165 Protein ID WP_003408528.1
Coordinates 1957913..1958125 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS09150 (M1772_09150) 1954391..1955578 - 1188 WP_003898992.1 nitrate transporter NarK -
M1772_RS09155 (M1772_09155) 1955865..1956149 + 285 WP_003408522.1 DUF1876 domain-containing protein -
M1772_RS09160 (M1772_09160) 1956163..1957845 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
M1772_RS09165 (M1772_09165) 1957913..1958125 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1772_RS09170 (M1772_09170) 1958125..1958373 + 249 WP_003408531.1 hypothetical protein Toxin
M1772_RS09175 (M1772_09175) 1958381..1959119 + 739 Protein_1810 hypothetical protein -
M1772_RS09180 (M1772_09180) 1959213..1960913 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
M1772_RS09185 (M1772_09185) 1961198..1961599 - 402 WP_273590140.1 hypothetical protein -
M1772_RS09190 (M1772_09190) 1961589..1962200 - 612 Protein_1813 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T243699 WP_003408531.1 NZ_CP096842:1958125-1958373 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T243699 NZ_OX458337:c74900-74523 [Pseudomonas syringae pv. tomato]
GTGAAAGGCGTCCTGGTAGACACCTCCGTTTGGGTTGAGCACTTTCGCAACAACAGTCCAGAACTGGTGAACTTGCTCAG
CCAGGACCGGGTACTCATACACCCCATGGTGATCGGAGAACTGGCGTGTGGTACGCCGCCTGATCGTTCGAACACCTTGA
CCGACCTTGGCGACCTACGAGGTGCACAACAACCCACGGTGAGTGAAGTCATCGCCTTTCTGAACACCCACAAGCTCTAT
GGCCTGGGCTGTGGGCTGGTGGATATGACGCTCCTGGCCTCCGCGTTGTTGAGCGGCACAGCGCTTTGGACGTTAGACAA
GCGCCTGGAGCGTTTGGCTAGCCGCATGGCCGTGTCATACCAGCCTTCTACTCACTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT243699 WP_003408528.1 NZ_CP096842:1957913-1958125 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT243699 NZ_OX458337:c75097-74897 [Pseudomonas syringae pv. tomato]
ATGAGAACGACTGTTACCATCGACGATGCGTTGTACCAACGTGCTCTGGAAGTCGCCGATCCGGCGATGGATAAGGCCGA
CCTGTTCCGTGAAGCCGTTCAGACGTTTGTGCGCATTCAAGCAGCTAAACGATTGATGGCCTTAGGGGCCACACTGCCAA
CGATGGAAGACATCGCCCGCCGACACGAGAAGGCACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References