243698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1937297..1937910 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag M1772_RS09060 Protein ID WP_003408465.1
Coordinates 1937297..1937686 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag M1772_RS09065 Protein ID WP_003408469.1
Coordinates 1937683..1937910 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS09025 (M1772_09025) 1932927..1933841 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
M1772_RS09030 (M1772_09030) 1933844..1934674 + 831 WP_003408448.1 cyclase family protein -
M1772_RS09035 (M1772_09035) 1934674..1935024 + 351 WP_003898986.1 cupin domain-containing protein -
M1772_RS09040 (M1772_09040) 1935077..1935894 + 818 Protein_1784 3-keto-5-aminohexanoate cleavage protein -
M1772_RS09045 (M1772_09045) 1935908..1936687 + 780 WP_003408460.1 IclR family transcriptional regulator -
M1772_RS09055 (M1772_09055) 1937118..1937249 + 132 Protein_1786 IS3 family transposase -
M1772_RS09060 (M1772_09060) 1937297..1937686 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
M1772_RS09065 (M1772_09065) 1937683..1937910 - 228 WP_003408469.1 antitoxin Antitoxin
M1772_RS09070 (M1772_09070) 1938128..1939612 + 1485 WP_010950580.1 biotin carboxylase -
M1772_RS09075 (M1772_09075) 1939609..1940856 + 1248 WP_003408476.1 serine hydrolase -
M1772_RS09080 (M1772_09080) 1940899..1941318 - 420 WP_003408483.1 hypothetical protein -
M1772_RS09085 (M1772_09085) 1941308..1942018 - 711 WP_183078454.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T243698 WP_003408465.1 NZ_CP096842:c1937686-1937297 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T243698 NZ_OX458337:8085-8504 [Pseudomonas syringae pv. tomato]
ATGATCCTGCTCGATACGAACGTAATTTCAGAACCGCAGCGCCGAGAGCCCAATGCCCACGTCCTTGACTGGATCGACGC
ACAAGCGCTGGAAACGCTTTATATGTCCACCATCACGGTAGCCGAGTTGCGTGCTGGTATCGCGCTGATGCCTGTCGGAA
AACGCCAGGATAGCTTGCGTGAAAACCTGGAAAAGCACCTGCTGCCGATGTTCGCCAATAGGGTGCTGTCGTTCGATATG
ACTTGTACGAAGGCTTATGCCGAGCTGCTGGCCAAGTCCCGCGCAGCCGGGTTGGCGGTCGAAACGGCAGATGCCTTCAT
TGCAGCCATCGCCCTCGCCAACGGCTTCACCGTCGCCACCCGTGACACTGGCCCTTTTGAGGCTGCCGGGTTGAACGTCA
TTAACCCCTGGGAAGCGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT243698 WP_003408469.1 NZ_CP096842:c1937910-1937683 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT243698 NZ_OX458337:7831-8088 [Pseudomonas syringae pv. tomato]
GTGGCAAACGTGAACGTAAGAAATCTACCCGATGAAGTGCATCGGGCCATCCGCATCCAAGCTGCCCTGCACGGGCGCAG
CACCGAGGCCGAAATACGCGACATCTTGGAGCGGGCGGCGAGACCCGAGGGACGTGTGAAACTTGGCTCGTTCCTGGCTT
CTATTGCCCGTGAGGTTGGTGGTCTGACCGATAAAGAACACACCTTGTTTGAGAACACGCGCATCACGTCTCCGGCCCGT
GCGGTGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References