Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 1389718..1390277 | Replicon | chromosome |
| Accession | NZ_CP096842 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb3114 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0THS1 |
| Locus tag | M1772_RS06650 | Protein ID | WP_003898789.1 |
| Coordinates | 1389718..1390011 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0THS2 |
| Locus tag | M1772_RS06655 | Protein ID | WP_003406322.1 |
| Coordinates | 1390008..1390277 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1772_RS06625 (M1772_06620) | 1385311..1385571 | + | 261 | WP_003406302.1 | type II toxin-antitoxin system antitoxin VapB33 | - |
| M1772_RS06630 (M1772_06625) | 1385568..1385999 | + | 432 | WP_003406304.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1772_RS06635 (M1772_06630) | 1386022..1387710 | - | 1689 | WP_003910308.1 | PE family protein | - |
| M1772_RS06640 (M1772_06635) | 1387890..1388750 | + | 861 | WP_003406306.1 | glycine betaine ABC transporter substrate-binding protein | - |
| M1772_RS06645 (M1772_06640) | 1388831..1389661 | - | 831 | WP_003898788.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| M1772_RS06650 (M1772_06645) | 1389718..1390011 | - | 294 | WP_003898789.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| M1772_RS06655 (M1772_06650) | 1390008..1390277 | - | 270 | WP_003406322.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| M1772_RS06660 (M1772_06655) | 1390390..1394085 | - | 3696 | WP_010950509.1 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit | - |
| M1772_RS06665 (M1772_06660) | 1394227..1395015 | - | 789 | WP_010950510.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11031.57 Da Isoelectric Point: 9.6275
>T243693 WP_003898789.1 NZ_CP096842:c1390011-1389718 [Mycobacterium tuberculosis variant bovis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
Download Length: 294 bp
>T243693 NZ_OX458335:467850-468425 [Pseudomonas syringae pv. tomato]
ATGAGGCATTCGCCGTTTACAGCTTTCTATGACGCCAACGTCCTATACCCGGCACCGCTTCGTGACTTTCTGATGCACTT
GGCATTGACTGGCGTGTACCGCGCACGCTGGTCTTCTCAAATTCATGACGAGTGGAAGCGCAACCTTCTGATCAATCGTC
CAGAGCTTACCCGTGAGCAACTGGATCGCACGTCTGCGCTGATGGATAAGGCAGTGCCGGACGGTCTGGTATCTGATTAC
CAGTCGCTAATTGAAGGGCTTAAGCTGCCTGACGCCGATGATCGTCATGTGCTGGCGGCTGCAATCAAGTGCAATGCCTC
TGTCATCGTGACATTCAAACTCAAGGACTTTCCGAAAGACGTCCTCGATACGTTCGATATGGAGCCCTTGCACCCGGATG
ATTTCATTGCCGACCTTTGGGATCTCGACAAAGCCGCTGTTCTCGAAGCCGCACAACGGCAGCGAGCATCTTTGAGAAAC
CCGGCACACAGTGCAAGGCAATACCTCGATAAGCTGCTGCAGCAGAAGCTTCCCGAGACTGTAAAACTGCTTTCGGATTT
TGAGTTTCTGATCTGA
ATGAGGCATTCGCCGTTTACAGCTTTCTATGACGCCAACGTCCTATACCCGGCACCGCTTCGTGACTTTCTGATGCACTT
GGCATTGACTGGCGTGTACCGCGCACGCTGGTCTTCTCAAATTCATGACGAGTGGAAGCGCAACCTTCTGATCAATCGTC
CAGAGCTTACCCGTGAGCAACTGGATCGCACGTCTGCGCTGATGGATAAGGCAGTGCCGGACGGTCTGGTATCTGATTAC
CAGTCGCTAATTGAAGGGCTTAAGCTGCCTGACGCCGATGATCGTCATGTGCTGGCGGCTGCAATCAAGTGCAATGCCTC
TGTCATCGTGACATTCAAACTCAAGGACTTTCCGAAAGACGTCCTCGATACGTTCGATATGGAGCCCTTGCACCCGGATG
ATTTCATTGCCGACCTTTGGGATCTCGACAAAGCCGCTGTTCTCGAAGCCGCACAACGGCAGCGAGCATCTTTGAGAAAC
CCGGCACACAGTGCAAGGCAATACCTCGATAAGCTGCTGCAGCAGAAGCTTCCCGAGACTGTAAAACTGCTTTCGGATTT
TGAGTTTCTGATCTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9766.97 Da Isoelectric Point: 4.8615
>AT243693 WP_003406322.1 NZ_CP096842:c1390277-1390008 [Mycobacterium tuberculosis variant bovis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
Download Length: 270 bp
>AT243693 NZ_OX458335:467386-467853 [Pseudomonas syringae pv. tomato]
ATGAGCAGCGCAGACGCCACTCGCACCGTTCTTCCTGGGGAGAAAGAAATCGCTGCGGCGGTTGAATCAAGTCGGCAATT
AGCCGCGTTTCTTACAACGAAATGTGACACCCAGCGCATTGAGCTTGTGGACGAAACGCAACAGCGCGAAGTCGTCGAGC
TGCCTATGTTTGCGCTCCGTTTGCTCGGCGAAATTCTCAGTGAGCTTGCGCTGGGTAACGCCGTCAAGGTGGTCCCCATT
CATGCTGAACTCACTACTCAGGAAGCAGCAGACATGCTCAATGTGTCCCGGCCTCATCTGGTGAAGATGCTGGACCAAGG
CATGTTGCCGCACACTAAAACCGGCAGGCACCGCCGAGTCAAATTTGCTGATTTGATGAGCTACAAGCAGCAGCGCGACC
AGGCAAGTCGCGAAGCCATGGACGAGTTAGCCGCGCAAGCCCAAGAACTAGGGATGGGATATGAATGA
ATGAGCAGCGCAGACGCCACTCGCACCGTTCTTCCTGGGGAGAAAGAAATCGCTGCGGCGGTTGAATCAAGTCGGCAATT
AGCCGCGTTTCTTACAACGAAATGTGACACCCAGCGCATTGAGCTTGTGGACGAAACGCAACAGCGCGAAGTCGTCGAGC
TGCCTATGTTTGCGCTCCGTTTGCTCGGCGAAATTCTCAGTGAGCTTGCGCTGGGTAACGCCGTCAAGGTGGTCCCCATT
CATGCTGAACTCACTACTCAGGAAGCAGCAGACATGCTCAATGTGTCCCGGCCTCATCTGGTGAAGATGCTGGACCAAGG
CATGTTGCCGCACACTAAAACCGGCAGGCACCGCCGAGTCAAATTTGCTGATTTGATGAGCTACAAGCAGCAGCGCGACC
AGGCAAGTCGCGAAGCCATGGACGAGTTAGCCGCGCAAGCCCAAGAACTAGGGATGGGATATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|