243690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1231753..1232384 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag M1772_RS05900 Protein ID WP_003405820.1
Coordinates 1231753..1232064 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag M1772_RS05905 Protein ID WP_003405836.1
Coordinates 1232064..1232384 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS05880 (M1772_05880) 1227235..1228659 - 1425 WP_003405805.1 class II fumarate hydratase -
M1772_RS05885 (M1772_05885) 1228690..1229778 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
M1772_RS05890 (M1772_05890) 1229834..1230478 + 645 WP_174813088.1 DUF4245 domain-containing protein -
M1772_RS05895 (M1772_05895) 1230485..1231641 - 1157 Protein_1161 AI-2E family transporter -
M1772_RS05900 (M1772_05900) 1231753..1232064 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
M1772_RS05905 (M1772_05905) 1232064..1232384 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
M1772_RS05910 (M1772_05910) 1232394..1233930 + 1537 Protein_1164 carboxylesterase/lipase family protein -
M1772_RS05915 (M1772_05915) 1233937..1235049 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
M1772_RS05920 (M1772_05920) 1235059..1235316 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
M1772_RS05925 (M1772_05925) 1235306..1236553 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
M1772_RS05930 (M1772_05930) 1236550..1237188 - 639 WP_011799158.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T243690 WP_003405820.1 NZ_CP096842:c1232064-1231753 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T243690 NZ_OX458332:c1592074-1591730 [Methylococcus capsulatus]
GTGACCTATGAACGCGGCCAGGTGGTGCGCGTGCCCTTCCCCTTCACCGACCGCGCCGCCAGCAAGAACCGCCCGGCGCT
GGTGCTCTCCGGCGCCAGCGCCTTCAACACCCCCGCCGGGCACGTGGTGCTGGCCATGATCACCTCGGCCAAGAATCCGC
CGTGGCCGCTCGATTACCCGATTGAAGACCTGGCCGCCGCCGGCCTGCCCGCGCCTTCGGTGGTGCGCTGCAAGCTGTTC
ACCCTGGATGCCCGGCTGATCCGCGGCGTGCTGGGGCGCTTGGCCGCCGCCGATGCCGCGCGCGCCAACACCGCTTTGGC
CCGCCTGCTGGGACCACTTTCATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT243690 WP_003405836.1 NZ_CP096842:c1232384-1232064 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT243690 NZ_OX458332:c1592294-1592064 [Methylococcus capsulatus]
ATGACCGCCGTGGCCAAAATCACCGCCAAGGGCCAGACCACCATCCCGGCGGACATCCGCGCCGCGCTCCACGTCGGTCC
CGGCGACCTCATCGCCTGGGAGATCGAACCCGACGGCAGCGCCCGCGTGCGCCGTGTGCAGCCGCTCGACATCGAATACC
TGAAGGCCGTCGAGGGCACCCTGTCCGAGTGGACGAGCCCGGCCGACGAGGAGGCCTACCGTGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References