243685

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 756839..757527 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag M1772_RS03505 Protein ID WP_003403386.1
Coordinates 756839..757276 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag M1772_RS03510 Protein ID WP_003911263.1
Coordinates 757273..757527 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS03475 (M1772_03475) 753090..754100 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1772_RS03480 (M1772_03480) 754488..754871 - 384 WP_003403365.1 ribonuclease VapC6 -
M1772_RS03485 (M1772_03485) 754966..755121 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
M1772_RS03490 (M1772_03490) 755197..755913 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1772_RS03495 (M1772_03495) 756189..756497 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
M1772_RS03500 (M1772_03500) 756484..756729 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
M1772_RS03505 (M1772_03505) 756839..757276 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
M1772_RS03510 (M1772_03510) 757273..757527 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
M1772_RS03515 (M1772_03515) 757641..760004 + 2364 WP_003403397.1 arylsulfatase AtsD -
M1772_RS03520 (M1772_03520) 760067..760393 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1772_RS03525 (M1772_03525) 760305..760643 + 339 WP_003403405.1 PIN domain-containing protein -
M1772_RS03530 (M1772_03530) 760640..760813 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T243685 WP_003403386.1 NZ_CP096842:c757276-756839 [Mycobacterium tuberculosis variant bovis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T243685 NZ_OX458329:c462854-462654 [Mobiluncus sp. Marseille-Q7826]
GTGAGCCTACGGGTTGTCCTGTCCAACCGCTTCAAAAAAGATTTGAAGCTGGCAAAAAAGCGCGGCCTGGATTTGGAACT
TCTCAACTCAGTCGTTACGCACCTTGCGAGCGGAAATACGCTTGACGCAAAGTACCGGGATCACGATCTCGGCGGTAACT
ACGCCACGTTCACCGATGAAGCGTCCCGCAGCACTAGCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT243685 WP_003911263.1 NZ_CP096842:c757527-757273 [Mycobacterium tuberculosis variant bovis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT243685 NZ_OX458329:c463126-462851 [Mobiluncus sp. Marseille-Q7826]
ATGACCAAAGTCAGTACGAACATAAATTTGGATGCAGATCTCAAACGGTCAGCGCAAGAGTTGCTGAAAGATTTGGGTAT
GGATCTCACCACTGCCGTGACAATTTTCCTTCGTCAAACCGTGCGTGACCAGGGGATACCTTTTAGAATCACGAGAGATA
TTCCCAATGCGGAAACTTTGGCCGCCTTACAGGAATATGAGGCAATGAAAGCGCACCCGGAACAATACAAGAGCTACGCG
AACTTCCAGGAAGCCATGGAGGACGTTCTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References