Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapC-mazE/PIN(toxin) |
Location | 756484..757276 | Replicon | chromosome |
Accession | NZ_CP096842 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb3114 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFB2 |
Locus tag | M1772_RS03505 | Protein ID | WP_003403386.1 |
Coordinates | 756839..757276 (-) | Length | 146 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TQE0 |
Locus tag | M1772_RS03500 | Protein ID | WP_003403381.1 |
Coordinates | 756484..756729 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1772_RS03470 (M1772_03470) | 751504..753009 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
M1772_RS03475 (M1772_03475) | 753090..754100 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
M1772_RS03480 (M1772_03480) | 754488..754871 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | - |
M1772_RS03485 (M1772_03485) | 754966..755121 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | - |
M1772_RS03490 (M1772_03490) | 755197..755913 | - | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
M1772_RS03495 (M1772_03495) | 756189..756497 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
M1772_RS03500 (M1772_03500) | 756484..756729 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
M1772_RS03505 (M1772_03505) | 756839..757276 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
M1772_RS03510 (M1772_03510) | 757273..757527 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
M1772_RS03515 (M1772_03515) | 757641..760004 | + | 2364 | WP_003403397.1 | arylsulfatase AtsD | - |
M1772_RS03520 (M1772_03520) | 760067..760393 | + | 327 | WP_003403401.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
M1772_RS03525 (M1772_03525) | 760305..760643 | + | 339 | WP_003403405.1 | PIN domain-containing protein | - |
M1772_RS03530 (M1772_03530) | 760640..760813 | + | 174 | WP_003898549.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 146 a.a. Molecular weight: 15245.39 Da Isoelectric Point: 5.1865
>T243684 WP_003403386.1 NZ_CP096842:c757276-756839 [Mycobacterium tuberculosis variant bovis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR
Download Length: 438 bp
>T243684 NZ_OX458329:c166484-166203 [Mobiluncus sp. Marseille-Q7826]
ATGAAGTACGAAGTCAGGTTTACGAGCCAGTTTAAGAAAGACGTGAAGCTCGCAAAAAAGCAGCACCGGGATTTAGAGAA
ACTTTTCAAAGTTATCCAGATTCTGGCAGAGGGAGGCTCTCTGCCAGAAAGATACCGCGACCACGGCCTTTCCGGCACTT
TCGCGGGGACCCGGGAATGCCACATCGAACCGGACTGGCTGCTGATTTACGAAATCCGCAGCAACGTGCTGGTGCTGATG
CTCTATCGACTCGGAACCCACGCGGAACTGTTCCAGAAATAA
ATGAAGTACGAAGTCAGGTTTACGAGCCAGTTTAAGAAAGACGTGAAGCTCGCAAAAAAGCAGCACCGGGATTTAGAGAA
ACTTTTCAAAGTTATCCAGATTCTGGCAGAGGGAGGCTCTCTGCCAGAAAGATACCGCGACCACGGCCTTTCCGGCACTT
TCGCGGGGACCCGGGAATGCCACATCGAACCGGACTGGCTGCTGATTTACGAAATCCGCAGCAACGTGCTGGTGCTGATG
CTCTATCGACTCGGAACCCACGCGGAACTGTTCCAGAAATAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9169.01 Da Isoelectric Point: 4.2070
>AT243684 WP_003403381.1 NZ_CP096842:c756729-756484 [Mycobacterium tuberculosis variant bovis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
Download Length: 246 bp
>AT243684 NZ_OX458329:c166753-166481 [Mobiluncus sp. Marseille-Q7826]
ATGACGACAACTAATTTAAATATCAGGACTGACAAAGAGGTCAAAGAACAGGCCGACCGCATCTTTTCGGAACTGGGTCT
CAACATGACCACGGCTATCAATATGTTCTTGCGCACTGCCATTCGCGAACAGGGAATTCCTTTCAAGTTGAGCCTGAATG
TCCCCAATGACGCTACCGCCGCCGCGATAAGGGAGGGTCGACGGATAGCAGACGACCCCAACGTTAAGGGCTACTCAACT
CTCGATGAGCTAAAGGCCGCCTTGGAAGTATGA
ATGACGACAACTAATTTAAATATCAGGACTGACAAAGAGGTCAAAGAACAGGCCGACCGCATCTTTTCGGAACTGGGTCT
CAACATGACCACGGCTATCAATATGTTCTTGCGCACTGCCATTCGCGAACAGGGAATTCCTTTCAAGTTGAGCCTGAATG
TCCCCAATGACGCTACCGCCGCCGCGATAAGGGAGGGTCGACGGATAGCAGACGACCCCAACGTTAAGGGCTACTCAACT
CTCGATGAGCTAAAGGCCGCCTTGGAAGTATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSW5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQE0 |