243679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 711763..712388 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag M1772_RS03260 Protein ID WP_003403218.1
Coordinates 711987..712388 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag M1772_RS03255 Protein ID WP_003403213.1
Coordinates 711763..711990 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS03230 (M1772_03230) 706942..707163 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1772_RS03235 (M1772_03235) 707305..707910 + 606 WP_003898526.1 hypothetical protein -
M1772_RS03240 (M1772_03240) 707929..710496 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
M1772_RS03245 (M1772_03245) 710580..711329 + 750 WP_003898528.1 hypothetical protein -
M1772_RS03250 (M1772_03250) 711326..711568 + 243 WP_003403210.1 hypothetical protein -
M1772_RS03255 (M1772_03255) 711763..711990 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
M1772_RS03260 (M1772_03260) 711987..712388 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
M1772_RS03265 (M1772_03265) 712517..712600 + 84 Protein_647 galactose-1-phosphate uridylyltransferase -
M1772_RS03270 (M1772_03270) 712619..713701 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1772_RS03275 (M1772_03275) 713698..714789 + 1092 WP_003403225.1 galactokinase -
M1772_RS03280 (M1772_03280) 715184..716341 + 1158 WP_003903091.1 hypothetical protein -
M1772_RS03285 (M1772_03285) 716352..717298 + 947 Protein_651 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T243679 WP_003403218.1 NZ_CP096842:711987-712388 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T243679 NZ_OX442412:3493887-3494228 [Salmonella enterica subsp. enterica serovar Rissen]
ATGCAAACCCAATACAACCACCCACACCGGGCGACCCCGTCACAACTATCGCCTGTCGAAATCTGGCAAAAACTGCTGAC
CCATTTACTGGCTAAACATTATGGCCTCGAACTCAGTGACACGCCGTTTAGCGTAGAGAAGGTGATTCAGGAACACATTG
ACGCCGGTATCACGCTGGCTAATGCCGTGAACTTTATTGTAGAGAAATACGAGCTGGTTCGTATCGATCGCAAGGGATTT
AGCTGGCAGGAACAATCACCCTATCTTCGGGCTGTAGACATTCTGCGGGCGCGACAGGCTACGGGTCTGTTGCGACGTCA
ACGCTATCTCGCGGCACACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT243679 WP_003403213.1 NZ_CP096842:711763-711990 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT243679 NZ_OX442412:3493502-3493843 [Salmonella enterica subsp. enterica serovar Rissen]
ATGGACACAAATGAAACACAATCCACGCCAGTATGGGGACTACGGAACGATGTCTTCCCGTCATTTGGCGCTCGGTTAGT
TCAGGAAGGTAATCACCTGCACTATCTGGCTGACCGGGCGGGTATTTATGGTGAATTTACCCCGGCGCAACTACAGACGC
TGGACGTCGTATTTCCAATGTTTATTAAACACATGGAGGCCGCTTTACGCACTGGCGCACTCAACCCGCGAGAGGCCAGA
CGCTTTACGACTGAACTCCGGGGCATAACCTGTGAAGCCGATACGTGCGGATCGTTCGGCTACGTTTATCTTTCGCTTTA
CCCAACCATCGTTAAAAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References