243674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445043..446054 Replicon chromosome
Accession NZ_CP096842
Organism Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag M1772_RS01945 Protein ID WP_003401859.1
Coordinates 445043..445636 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag M1772_RS01950 Protein ID WP_003401860.1
Coordinates 445665..446054 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1772_RS01925 (M1772_01925) 440692..442074 + 1383 WP_003898415.1 magnesium transporter -
M1772_RS01930 (M1772_01930) 442086..443120 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
M1772_RS01935 (M1772_01935) 443216..443899 + 684 WP_010950388.1 VTT domain-containing protein -
M1772_RS01940 (M1772_01940) 443888..445018 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
M1772_RS01945 (M1772_01945) 445043..445636 - 594 WP_003401859.1 zeta toxin family protein Toxin
M1772_RS01950 (M1772_01950) 445665..446054 - 390 WP_003401860.1 hypothetical protein Antitoxin
M1772_RS01955 (M1772_01955) 446135..447346 - 1212 WP_003401861.1 VWA domain-containing protein -
M1772_RS01960 (M1772_01960) 447352..447954 - 603 WP_003898417.1 SRPBCC family protein -
M1772_RS01965 (M1772_01965) 447968..448864 - 897 WP_003401863.1 MoxR family ATPase -
M1772_RS01970 (M1772_01970) 448861..449454 - 594 WP_003401864.1 NTP transferase domain-containing protein -
M1772_RS01975 (M1772_01975) 449451..450206 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T243674 WP_003401859.1 NZ_CP096842:c445636-445043 [Mycobacterium tuberculosis variant bovis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T243674 NZ_OX442412:2006215-2006433 [Salmonella enterica subsp. enterica serovar Rissen]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT243674 WP_003401860.1 NZ_CP096842:c446054-445665 [Mycobacterium tuberculosis variant bovis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT243674 NZ_OX442412:2005813-2006187 [Salmonella enterica subsp. enterica serovar Rissen]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References