Detailed information of TA system TA243672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0299-vapB/-
• Location: 364428..364999
• Replicon: chromosome
• Accession: NZ_CP096842
• Organism: Mycobacterium tuberculosis variant bovis strain Mb3114

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: M1772_RS01590
• Protein ID: WP_003401560.1
• Coordinates: 364428..364730 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: O07227
• Locus tag: M1772_RS01595
• Protein ID: WP_003401563.1
• Coordinates: 364778..364999 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1772_RS01570 (M1772_01570)	359852..360655	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
M1772_RS01575 (M1772_01575)	360665..362062	-	1398	WP_003401544.1	sulfatase	-
M1772_RS01580 (M1772_01580)	362241..364061	+	1821	WP_003401546.1	PE family protein	-
M1772_RS01585 (M1772_01585)	364204..364431	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	-
M1772_RS01590 (M1772_01590)	364428..364730	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
M1772_RS01595 (M1772_01595)	364778..364999	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	Antitoxin
M1772_RS01600 (M1772_01600)	364996..365421	+	426	WP_003401566.1	PIN domain nuclease	-
M1772_RS01605 (M1772_01605)	365557..366189	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
M1772_RS01610 (M1772_01610)	366186..367094	+	909	WP_003900117.1	protochlorophyllide reductase	-
M1772_RS01615 (M1772_01615)	367102..367692	-	591	WP_234712434.1	hypothetical protein	-
M1772_RS01620 (M1772_01620)	367685..367735	-	51	Protein_320	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (9-37)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T243672 WP_003401560.1 NZ_CP096842:364428-364730 [Mycobacterium tuberculosis variant bovis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T243672 NZ_OX442412:1008347-1008658 [Salmonella enterica subsp. enterica serovar Rissen]
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAAAGATTTCTCTTCTCCGGCAGAGCTACGAAAGGTCATACCGAGTCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTACTACAGGGAGAATAAAGAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8088.31 Da
• Isoelectric Point: 10.7177

>AT243672 WP_003401563.1 NZ_CP096842:364778-364999 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Nucleotide

• Length: 222 bp

>AT243672 NZ_OX442412:1008655-1009074 [Salmonella enterica subsp. enterica serovar Rissen]
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTGGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGCGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAAATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A829CG48