Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 71283..71916 | Replicon | chromosome |
Accession | NZ_CP096842 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb3114 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFC0 |
Locus tag | M1772_RS00365 | Protein ID | WP_003400580.1 |
Coordinates | 71515..71916 (+) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A7U4BR76 |
Locus tag | M1772_RS00360 | Protein ID | WP_011799070.1 |
Coordinates | 71283..71522 (+) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1772_RS00345 (M1772_00345) | 66579..68018 | + | 1440 | WP_003901784.1 | FAD-binding oxidoreductase | - |
M1772_RS00350 (M1772_00350) | 68074..68235 | + | 162 | WP_003899796.1 | hypothetical protein | - |
M1772_RS00355 (M1772_00355) | 68276..71216 | + | 2941 | Protein_67 | UPF0182 family protein | - |
M1772_RS00360 (M1772_00360) | 71283..71522 | + | 240 | WP_011799070.1 | hypothetical protein | Antitoxin |
M1772_RS00365 (M1772_00365) | 71515..71916 | + | 402 | WP_003400580.1 | type II toxin-antitoxin system ribonuclease VapC1 | Toxin |
M1772_RS00370 (M1772_00370) | 71968..74205 | - | 2238 | WP_003400583.1 | NADP-dependent isocitrate dehydrogenase | - |
M1772_RS00375 (M1772_00375) | 74323..74892 | - | 570 | WP_003400591.1 | TetR/AcrR family transcriptional regulator | - |
M1772_RS00380 (M1772_00380) | 74995..75906 | + | 912 | WP_003899798.1 | SDR family NAD(P)-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14339.44 Da Isoelectric Point: 4.8887
>T243670 WP_003400580.1 NZ_CP096842:71515-71916 [Mycobacterium tuberculosis variant bovis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR
Download Length: 402 bp
>T243670 NZ_OX419652:1915818-1915994 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCAGATGA
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCAGATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8745.89 Da Isoelectric Point: 8.5960
>AT243670 WP_011799070.1 NZ_CP096842:71283-71522 [Mycobacterium tuberculosis variant bovis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEVIEILEQALASTASPGISRETIEASRRELRGG
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEVIEILEQALASTASPGISRETIEASRRELRGG
Download Length: 240 bp
>AT243670 NZ_OX419652:c1916032-1915935 [Bacillus subtilis]
GAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTGGTACTCATCTGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAGCCG
CTTGCGTATACGCTTTTT
GAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTGGTACTCATCTGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAGCCG
CTTGCGTATACGCTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BR82 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BR76 |