243666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3659365..3660039 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag M1774_RS17260 Protein ID WP_003417282.1
Coordinates 3659365..3659793 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag M1774_RS17265 Protein ID WP_003417286.1
Coordinates 3659797..3660039 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS17235 (M1774_17235) 3655187..3655588 - 402 WP_003417264.1 cytidine deaminase -
M1774_RS17240 (M1774_17240) 3655825..3656163 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
M1774_RS17245 (M1774_17245) 3656160..3656594 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
M1774_RS17250 (M1774_17250) 3656723..3658495 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
M1774_RS17255 (M1774_17255) 3658495..3659286 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
M1774_RS17260 (M1774_17260) 3659365..3659793 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
M1774_RS17265 (M1774_17265) 3659797..3660039 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
M1774_RS17270 (M1774_17270) 3660161..3660775 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
M1774_RS17275 (M1774_17275) 3660772..3661437 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
M1774_RS17280 (M1774_17280) 3661438..3661971 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
M1774_RS17285 (M1774_17285) 3661968..3662342 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
M1774_RS17290 (M1774_17290) 3662439..3663443 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T243666 WP_003417282.1 NZ_CP096841:c3659793-3659365 [Mycobacterium tuberculosis variant bovis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T243666 NZ_OX419580:2726766-2726945 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT243666 WP_003417286.1 NZ_CP096841:c3660039-3659797 [Mycobacterium tuberculosis variant bovis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT243666 NZ_OX419580:c2727091-2726869 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References