Detailed information of TA system TA243651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2381368..2381897
• Replicon: chromosome
• Accession: NZ_CP096841
• Organism: Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: M1774_RS11125
• Protein ID: WP_003411124.1
• Coordinates: 2381368..2381685 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: M1774_RS11130
• Protein ID: WP_003411127.1
• Coordinates: 2381682..2381897 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1774_RS11095 (M1774_11105)	2376389..2377465	+	1077	WP_003411110.1	hypothetical protein	-
M1774_RS11100 (M1774_11110)	2377462..2377743	+	282	WP_003411112.1	DUF5703 family protein	-
M1774_RS11105 (M1774_11115)	2377779..2378852	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
M1774_RS11110 (M1774_11120)	2378857..2379387	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
M1774_RS11115 (M1774_11125)	2379435..2380781	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
M1774_RS11125 (M1774_11135)	2381368..2381685	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1774_RS11130 (M1774_11140)	2381682..2381897	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
M1774_RS11135 (M1774_11145)	2382152..2383210	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
M1774_RS11140 (M1774_11150)	2383340..2383696	-	357	WP_003411130.1	hypothetical protein	-
M1774_RS11145 (M1774_11155)	2383791..2384573	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
M1774_RS11150 (M1774_11160)	2384841..2385131	-	291	WP_003900476.1	YggT family protein	-
M1774_RS11155 (M1774_11165)	2385293..2385949	-	657	WP_003411133.1	cell division protein SepF	-
M1774_RS11160 (M1774_11170)	2386015..2386791	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T243651 WP_003411124.1 NZ_CP096841:c2381685-2381368 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T243651 NZ_OX419578:513606-513956 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT243651 WP_003411127.1 NZ_CP096841:c2381897-2381682 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT243651 NZ_OX419578:513320-513601 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4