243650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2344588..2345283 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag M1774_RS10920 Protein ID WP_003410811.1
Coordinates 2344588..2345022 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag M1774_RS10925 Protein ID WP_003410814.1
Coordinates 2345029..2345283 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS10910 (M1774_10920) 2340742..2343783 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
M1774_RS10915 (M1774_10925) 2343776..2344609 + 834 WP_003899172.1 SWIM zinc finger family protein -
M1774_RS10920 (M1774_10930) 2344588..2345022 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
M1774_RS10925 (M1774_10935) 2345029..2345283 - 255 WP_003410814.1 antitoxin Antitoxin
M1774_RS10930 (M1774_10940) 2345299..2345556 - 258 WP_003410816.1 hypothetical protein -
M1774_RS10935 (M1774_10945) 2346503..2346799 + 297 WP_003410820.1 PE family protein -
M1774_RS10940 (M1774_10950) 2346855..2347586 + 732 WP_003900467.1 PPE family protein -
M1774_RS10945 (M1774_10955) 2348126..2348872 - 747 WP_003901330.1 proteasome subunit alpha -
M1774_RS10950 (M1774_10960) 2348869..2349744 - 876 WP_003411023.1 proteasome subunit beta -
M1774_RS10955 (M1774_10965) 2349741..2349935 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T243650 WP_003410811.1 NZ_CP096841:c2345022-2344588 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T243650 NZ_OX419577:1867232-1867483 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGTAAACATGAAACGATTCTCATTATGGTT
TACCAATATTACATTCATTGGCTTATTCTTAATGTTTCAACTCATTAAAGATTACTTCAGCAGCGAAGCACAAACACTAA
TCAATACAATATTTGTAGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTTTGCTTTCCTAAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT243650 WP_003410814.1 NZ_CP096841:c2345283-2345029 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT243650 NZ_OX419577:c1867254-1867154 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTACGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References