Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2209033..2209931 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag M1774_RS10310 Protein ID WP_003410001.1
Coordinates 2209033..2209593 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag M1774_RS10315 Protein ID WP_003410003.1
Coordinates 2209590..2209931 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS10280 (M1774_10290) 2204202..2204855 - 654 WP_003409976.1 cutinase Cfp21 -
M1774_RS10285 (M1774_10295) 2204970..2205200 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1774_RS10290 (M1774_10300) 2205285..2206196 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1774_RS10295 (M1774_10305) 2206305..2206904 + 600 WP_003409989.1 L-lysine exporter -
M1774_RS10300 (M1774_10310) 2207320..2207748 + 429 WP_003409992.1 cellulose-binding protein -
M1774_RS10305 (M1774_10315) 2207974..2208513 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1774_RS10310 (M1774_10320) 2209033..2209593 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
M1774_RS10315 (M1774_10325) 2209590..2209931 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
M1774_RS10320 (M1774_10330) 2210017..2210274 + 258 WP_003410006.1 hypothetical protein -
M1774_RS10325 (M1774_10335) 2210175..2210510 - 336 WP_003410009.1 dehydrogenase -
M1774_RS10330 (M1774_10340) 2210599..2210943 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
M1774_RS10335 (M1774_10345) 2210937..2211185 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
M1774_RS10340 (M1774_10350) 2211285..2213600 - 2316 WP_273620539.1 cation transporter ATPase CptG -
M1774_RS10345 (M1774_10355) 2213597..2213869 - 273 WP_003410017.1 DUF1490 family protein -
M1774_RS10350 (M1774_10360) 2213922..2214278 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T243645 WP_003410001.1 NZ_CP096841:c2209593-2209033 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T243645 NZ_OX419576:c1325698-1324952 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATATGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT243645 WP_003410003.1 NZ_CP096841:c2209931-2209590 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT243645 NZ_OX419576:c1324952-1324782 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References