Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2192694..2193238 | Replicon | chromosome |
| Accession | NZ_CP096841 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb0820 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | M1774_RS10205 | Protein ID | WP_003409896.1 |
| Coordinates | 2192694..2192990 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | M1774_RS10210 | Protein ID | WP_003409899.1 |
| Coordinates | 2192987..2193238 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1774_RS10150 (M1774_10160) | 2187728..2188078 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1774_RS10155 (M1774_10165) | 2188089..2188990 | - | 902 | Protein_2006 | hypothetical protein | - |
| M1774_RS10160 (M1774_10170) | 2189011..2189202 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1774_RS10165 (M1774_10175) | 2189203..2189499 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1774_RS10170 (M1774_10180) | 2189739..2189954 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1774_RS10175 (M1774_10185) | 2189951..2190262 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1774_RS10180 (M1774_10190) | 2190236..2190757 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1774_RS10185 (M1774_10195) | 2190732..2191109 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| M1774_RS10190 (M1774_10200) | 2191151..2191600 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| M1774_RS10195 (M1774_10205) | 2191597..2192142 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1774_RS10200 (M1774_10210) | 2192031..2192645 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1774_RS10205 (M1774_10215) | 2192694..2192990 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1774_RS10210 (M1774_10220) | 2192987..2193238 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| M1774_RS10215 (M1774_10225) | 2193225..2193719 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1774_RS10220 (M1774_10230) | 2193879..2194286 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1774_RS10225 (M1774_10235) | 2194290..2194562 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1774_RS10230 (M1774_10240) | 2194595..2195815 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| M1774_RS10235 (M1774_10245) | 2196714..2197019 | + | 306 | Protein_2022 | ABC transporter permease | - |
| M1774_RS10240 (M1774_10250) | 2197015..2197095 | + | 81 | Protein_2023 | hypothetical protein | - |
| M1774_RS10245 (M1774_10255) | 2197203..2198050 | + | 848 | Protein_2024 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T243643 WP_003409896.1 NZ_CP096841:c2192990-2192694 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T243643 NZ_OX419575:2565723-2565902 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT243643 WP_003409899.1 NZ_CP096841:c2193238-2192987 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT243643 NZ_OX419575:c2566048-2565826 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |