243639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1930056..1930669 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag M1774_RS08995 Protein ID WP_003408465.1
Coordinates 1930056..1930445 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag M1774_RS09000 Protein ID WP_003408469.1
Coordinates 1930442..1930669 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS08960 (M1774_08970) 1925686..1926600 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
M1774_RS08965 (M1774_08975) 1926603..1927433 + 831 WP_003408448.1 cyclase family protein -
M1774_RS08970 (M1774_08980) 1927433..1927783 + 351 WP_003898986.1 cupin domain-containing protein -
M1774_RS08975 (M1774_08985) 1927836..1928653 + 818 Protein_1771 3-keto-5-aminohexanoate cleavage protein -
M1774_RS08980 (M1774_08990) 1928667..1929446 + 780 WP_003408460.1 IclR family transcriptional regulator -
M1774_RS08990 (M1774_09000) 1929877..1930008 + 132 Protein_1773 IS3 family transposase -
M1774_RS08995 (M1774_09005) 1930056..1930445 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
M1774_RS09000 (M1774_09010) 1930442..1930669 - 228 WP_003408469.1 antitoxin Antitoxin
M1774_RS09005 (M1774_09015) 1930887..1932371 + 1485 WP_010950580.1 biotin carboxylase -
M1774_RS09010 (M1774_09020) 1932368..1933615 + 1248 WP_003408476.1 serine hydrolase -
M1774_RS09015 (M1774_09025) 1933658..1934077 - 420 WP_003408483.1 hypothetical protein -
M1774_RS09020 (M1774_09030) 1934067..1934777 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T243639 WP_003408465.1 NZ_CP096841:c1930445-1930056 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T243639 NZ_OX419573:2325359-2325475 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT243639 WP_003408469.1 NZ_CP096841:c1930669-1930442 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT243639 NZ_OX419573:c2325655-2325470 [Bacillus subtilis]
AATGATACAAATAATTATTTATTGCATTTTGATTTGTGGAAATGCATAAAATAAAAAAGACCTGGGGTGCGCTAACACCC
ACTGGTCATTGTTTGTACAAAAAGCCGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGT
GTCCAAACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References