243637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1689146..1689762 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag M1774_RS07965 Protein ID WP_003407593.1
Coordinates 1689445..1689762 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag M1774_RS07960 Protein ID WP_003900349.1
Coordinates 1689146..1689448 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS07950 (M1774_07960) 1685032..1686879 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
M1774_RS07955 (M1774_07965) 1686880..1689132 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
M1774_RS07960 (M1774_07970) 1689146..1689448 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
M1774_RS07965 (M1774_07975) 1689445..1689762 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
M1774_RS07970 (M1774_07980) 1689759..1690763 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
M1774_RS07975 (M1774_07985) 1690816..1692105 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
M1774_RS07980 (M1774_07990) 1692178..1692795 - 618 WP_003407606.1 class I SAM-dependent methyltransferase -
M1774_RS07985 (M1774_07995) 1693009..1693200 - 192 WP_003407609.1 dodecin family protein -
M1774_RS07990 (M1774_08000) 1693282..1693680 + 399 WP_003900351.1 hypothetical protein -
M1774_RS07995 (M1774_08005) 1693725..1694753 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T243637 WP_003407593.1 NZ_CP096841:1689445-1689762 [Mycobacterium tuberculosis variant bovis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T243637 NZ_OX419573:c2272182-2272006 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAATCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCA
AACGTATACGCAGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT243637 WP_003900349.1 NZ_CP096841:1689146-1689448 [Mycobacterium tuberculosis variant bovis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT243637 NZ_OX419573:2271965-2272065 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCTGCGTATACGTTTGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References