243636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1576611..1577266 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag M1774_RS07465 Protein ID WP_003407268.1
Coordinates 1576611..1577012 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag M1774_RS07470 Protein ID WP_003407272.1
Coordinates 1577009..1577266 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS07450 (M1774_07460) 1572455..1573840 - 1386 WP_003407260.1 cytochrome P450 -
M1774_RS07455 (M1774_07465) 1573918..1574952 + 1035 WP_003407264.1 AraC family transcriptional regulator -
M1774_RS07460 (M1774_07470) 1574998..1576356 - 1359 WP_273620604.1 PE family protein -
M1774_RS07465 (M1774_07475) 1576611..1577012 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
M1774_RS07470 (M1774_07480) 1577009..1577266 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
M1774_RS07475 (M1774_07485) 1577349..1578308 - 960 WP_003407276.1 alpha/beta hydrolase -
M1774_RS07480 (M1774_07490) 1578333..1579295 - 963 WP_003407279.1 alpha/beta hydrolase -
M1774_RS07485 (M1774_07495) 1579294..1580031 + 738 WP_031647000.1 lysoplasmalogenase -
M1774_RS07490 (M1774_07500) 1580112..1582079 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T243636 WP_003407268.1 NZ_CP096841:c1577012-1576611 [Mycobacterium tuberculosis variant bovis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T243636 NZ_OX419573:c2271987-2271736 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGTAAACATGAAACGATTCTCTTTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATTAAGGATTACTTCAGCAGCGAAGCACAAACACTAA
TCAACACAATATTTGTAGTCACATGTATCATTGCCATACTGTTATGGATCATCTATTTTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT243636 WP_003407272.1 NZ_CP096841:c1577266-1577009 [Mycobacterium tuberculosis variant bovis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT243636 NZ_OX419573:2271965-2272065 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCTGCGTATACGTTTGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References