243632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1242564..1243132 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag M1774_RS05965 Protein ID WP_003405865.1
Coordinates 1242758..1243132 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag M1774_RS05960 Protein ID WP_003405863.1
Coordinates 1242564..1242761 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS05940 (M1774_05945) 1238605..1239243 - 639 WP_003898730.1 lipid droplet-associated protein -
M1774_RS05945 (M1774_05950) 1239333..1240340 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
M1774_RS05950 (M1774_05955) 1240357..1241340 - 984 WP_003898731.1 hypothetical protein -
M1774_RS05955 (M1774_05960) 1241403..1242476 + 1074 WP_003405860.1 redox-regulated ATPase YchF -
M1774_RS05960 (M1774_05965) 1242564..1242761 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1774_RS05965 (M1774_05970) 1242758..1243132 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
M1774_RS05970 (M1774_05975) 1243335..1244033 + 699 WP_010950494.1 hypothetical protein -
M1774_RS05975 (M1774_05980) 1244151..1244336 + 186 WP_003901093.1 hypothetical protein -
M1774_RS05980 (M1774_05985) 1244263..1244538 - 276 WP_003405867.1 hypothetical protein -
M1774_RS05985 (M1774_05990) 1244781..1245104 + 324 WP_003405871.1 putative quinol monooxygenase -
M1774_RS05990 (M1774_05995) 1245119..1245817 - 699 WP_031646953.1 hypothetical protein -
M1774_RS05995 (M1774_06000) 1245851..1246060 + 210 WP_003911400.1 hypothetical protein -
M1774_RS06000 (M1774_06005) 1246012..1246782 - 771 Protein_1182 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T243632 WP_003405865.1 NZ_CP096841:1242758-1243132 [Mycobacterium tuberculosis variant bovis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T243632 NZ_OX419570:2147211-2147303 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT243632 WP_003405863.1 NZ_CP096841:1242564-1242761 [Mycobacterium tuberculosis variant bovis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT243632 NZ_OX419570:c2147457-2147284 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TH08

Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References