243621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 718750..719399 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag M1774_RS03305 Protein ID WP_003403236.1
Coordinates 719004..719399 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag M1774_RS03300 Protein ID WP_003403235.1
Coordinates 718750..719004 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS03275 (M1774_03275) 713875..713958 + 84 Protein_649 galactose-1-phosphate uridylyltransferase -
M1774_RS03280 (M1774_03280) 713977..715059 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1774_RS03285 (M1774_03285) 715056..716147 + 1092 WP_003403225.1 galactokinase -
M1774_RS03290 (M1774_03290) 716542..717699 + 1158 WP_003903091.1 hypothetical protein -
M1774_RS03295 (M1774_03295) 717710..718657 + 948 WP_003403232.1 DUF732 domain-containing protein -
M1774_RS03300 (M1774_03300) 718750..719004 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
M1774_RS03305 (M1774_03305) 719004..719399 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
M1774_RS03310 (M1774_03310) 719493..720233 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
M1774_RS03315 (M1774_03315) 720365..720625 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1774_RS03320 (M1774_03320) 720622..721029 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
M1774_RS03325 (M1774_03325) 721101..722252 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
M1774_RS03330 (M1774_03330) 722345..724072 - 1728 WP_010950423.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T243621 WP_003403236.1 NZ_CP096841:719004-719399 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T243621 NZ_OX419567:2563876-2564055 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT243621 WP_003403235.1 NZ_CP096841:718750-719004 [Mycobacterium tuberculosis variant bovis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT243621 NZ_OX419567:c2564201-2563979 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References