243620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 713121..713746 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M1774_RS03270 Protein ID WP_273620590.1
Coordinates 713345..713746 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag M1774_RS03265 Protein ID WP_003403213.1
Coordinates 713121..713348 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS03240 (M1774_03240) 708300..708521 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1774_RS03245 (M1774_03245) 708663..709268 + 606 WP_003898526.1 hypothetical protein -
M1774_RS03250 (M1774_03250) 709287..711854 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
M1774_RS03255 (M1774_03255) 711938..712687 + 750 WP_003898528.1 hypothetical protein -
M1774_RS03260 (M1774_03260) 712684..712926 + 243 WP_003403210.1 hypothetical protein -
M1774_RS03265 (M1774_03265) 713121..713348 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
M1774_RS03270 (M1774_03270) 713345..713746 + 402 WP_273620590.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
M1774_RS03275 (M1774_03275) 713875..713958 + 84 Protein_649 galactose-1-phosphate uridylyltransferase -
M1774_RS03280 (M1774_03280) 713977..715059 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1774_RS03285 (M1774_03285) 715056..716147 + 1092 WP_003403225.1 galactokinase -
M1774_RS03290 (M1774_03290) 716542..717699 + 1158 WP_003903091.1 hypothetical protein -
M1774_RS03295 (M1774_03295) 717710..718657 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13865.70 Da        Isoelectric Point: 6.0394

>T243620 WP_273620590.1 NZ_CP096841:713345-713746 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAGHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T243620 NZ_OX419567:2089927-2090019 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT243620 WP_003403213.1 NZ_CP096841:713121-713348 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT243620 NZ_OX419567:c2090173-2090000 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References