Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 364756..365399 | Replicon | chromosome |
Accession | NZ_CP096841 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb0820 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFB8 |
Locus tag | M1774_RS01600 | Protein ID | WP_003401566.1 |
Coordinates | 364974..365399 (+) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | O07227 |
Locus tag | M1774_RS01595 | Protein ID | WP_003401563.1 |
Coordinates | 364756..364977 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1774_RS01570 (M1774_01570) | 359830..360633 | - | 804 | WP_003401540.1 | Stf0 family sulphotransferase | - |
M1774_RS01575 (M1774_01575) | 360643..362040 | - | 1398 | WP_003401544.1 | sulfatase | - |
M1774_RS01580 (M1774_01580) | 362219..364039 | + | 1821 | WP_273620582.1 | PE family protein | - |
M1774_RS01585 (M1774_01585) | 364182..364409 | + | 228 | WP_003401555.1 | ribbon-helix-helix protein, CopG family | - |
M1774_RS01590 (M1774_01590) | 364406..364708 | + | 303 | WP_003401560.1 | toxin-antitoxin system toxin | - |
M1774_RS01595 (M1774_01595) | 364756..364977 | + | 222 | WP_003401563.1 | type II toxin-antitoxin system antitoxin VapB2 | Antitoxin |
M1774_RS01600 (M1774_01600) | 364974..365399 | + | 426 | WP_003401566.1 | PIN domain nuclease | Toxin |
M1774_RS01605 (M1774_01605) | 365535..366167 | + | 633 | WP_003401571.1 | TetR/AcrR family transcriptional regulator | - |
M1774_RS01610 (M1774_01610) | 366164..367072 | + | 909 | WP_003900117.1 | protochlorophyllide reductase | - |
M1774_RS01615 (M1774_01615) | 367080..367670 | - | 591 | WP_234712434.1 | hypothetical protein | - |
M1774_RS01620 (M1774_01620) | 367663..367713 | - | 51 | Protein_320 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15713.90 Da Isoelectric Point: 5.6002
>T243614 WP_003401566.1 NZ_CP096841:364974-365399 [Mycobacterium tuberculosis variant bovis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
Download Length: 426 bp
>T243614 NZ_OX419564:c2205368-2205192 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
GTGCTTGAGAAAGTGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8088.31 Da Isoelectric Point: 10.7177
>AT243614 WP_003401563.1 NZ_CP096841:364756-364977 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
Download Length: 222 bp
>AT243614 NZ_OX419564:2205309-2205409 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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