243613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 364406..364977 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag M1774_RS01590 Protein ID WP_003401560.1
Coordinates 364406..364708 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag M1774_RS01595 Protein ID WP_003401563.1
Coordinates 364756..364977 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS01570 (M1774_01570) 359830..360633 - 804 WP_003401540.1 Stf0 family sulphotransferase -
M1774_RS01575 (M1774_01575) 360643..362040 - 1398 WP_003401544.1 sulfatase -
M1774_RS01580 (M1774_01580) 362219..364039 + 1821 WP_273620582.1 PE family protein -
M1774_RS01585 (M1774_01585) 364182..364409 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
M1774_RS01590 (M1774_01590) 364406..364708 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
M1774_RS01595 (M1774_01595) 364756..364977 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
M1774_RS01600 (M1774_01600) 364974..365399 + 426 WP_003401566.1 PIN domain nuclease -
M1774_RS01605 (M1774_01605) 365535..366167 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
M1774_RS01610 (M1774_01610) 366164..367072 + 909 WP_003900117.1 protochlorophyllide reductase -
M1774_RS01615 (M1774_01615) 367080..367670 - 591 WP_234712434.1 hypothetical protein -
M1774_RS01620 (M1774_01620) 367663..367713 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T243613 WP_003401560.1 NZ_CP096841:364406-364708 [Mycobacterium tuberculosis variant bovis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T243613 NZ_OX419564:c2205368-2205192 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT243613 WP_003401563.1 NZ_CP096841:364756-364977 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT243613 NZ_OX419564:2205151-2205251 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References