Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 71280..71913 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag M1774_RS00365 Protein ID WP_003400580.1
Coordinates 71512..71913 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4BR76
Locus tag M1774_RS00360 Protein ID WP_011799070.1
Coordinates 71280..71519 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS00345 (M1774_00345) 66577..68016 + 1440 WP_003901784.1 FAD-binding oxidoreductase -
M1774_RS00350 (M1774_00350) 68072..68233 + 162 WP_003899796.1 hypothetical protein -
M1774_RS00355 (M1774_00355) 68274..71213 + 2940 WP_003901785.1 UPF0182 family protein -
M1774_RS00360 (M1774_00360) 71280..71519 + 240 WP_011799070.1 hypothetical protein Antitoxin
M1774_RS00365 (M1774_00365) 71512..71913 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
M1774_RS00370 (M1774_00370) 71965..74202 - 2238 WP_003400583.1 NADP-dependent isocitrate dehydrogenase -
M1774_RS00375 (M1774_00375) 74320..74889 - 570 WP_003400591.1 TetR/AcrR family transcriptional regulator -
M1774_RS00380 (M1774_00380) 74992..75903 + 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T243611 WP_003400580.1 NZ_CP096841:71512-71913 [Mycobacterium tuberculosis variant bovis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

>T243611 NZ_OX419564:c1321140-1320394 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTATATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTAGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAGCCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8745.89 Da        Isoelectric Point: 8.5960

>AT243611 WP_011799070.1 NZ_CP096841:71280-71519 [Mycobacterium tuberculosis variant bovis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEVIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp

>AT243611 NZ_OX419564:c1320394-1320224 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BR76

References