Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3754225..3754892 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag M1780_RS17635 Protein ID WP_003417916.1
Coordinates 3754225..3754617 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag M1780_RS17640 Protein ID WP_003912214.1
Coordinates 3754617..3754892 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS17620 (M1780_17615) 3749595..3751433 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
M1780_RS17625 (M1780_17620) 3751430..3752419 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
M1780_RS17630 (M1780_17625) 3752419..3753471 - 1053 WP_273610410.1 polyprenyl synthetase family protein -
M1780_RS17635 (M1780_17630) 3754225..3754617 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
M1780_RS17640 (M1780_17635) 3754617..3754892 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1780_RS17645 (M1780_17640) 3755074..3756445 + 1372 Protein_3485 ISNCY family transposase -
M1780_RS17650 (M1780_17645) 3756635..3758887 + 2253 WP_011799349.1 PE family protein -
M1780_RS17655 (M1780_17650) 3758958..3759830 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3755768..3756445 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T243609 WP_003417916.1 NZ_CP096840:c3754617-3754225 [Mycobacterium tuberculosis variant bovis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T243609 NZ_OX419563:2639155-2639334 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT243609 WP_003912214.1 NZ_CP096840:c3754892-3754617 [Mycobacterium tuberculosis variant bovis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT243609 NZ_OX419563:c2639480-2639258 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References